ReviewFrontiers in neuroscience2015
Functional optical probing of the hippocampal trisynaptic circuit in vitro: network dynamics, filter properties, and polysynaptic induction of CA1 LTP.
Review in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 82 citations in OpenAlex.
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- Longitudinal analysis of hippocampal subfield atrophy and network centrality associated with cognitive decline in Alzheimer's disease progression.Medical physics · 2026Article
- Functional transition of CA2 pyramidal neurons along the proximodistal axis determines resonance frequency preference.Scientific reports · 2026Article
- VTA-forebrain connectivity moderates adaptive behavior.Brain structure & function · 2026Review
- Lipid Metabolism-Driven CNS Repair via Targeted EV Delivery of PAF to Neurons.Journal of extracellular vesicles · 2026Article
- ATRX function beyond hippocampal CA1 is required for cognitive deficits in mouse models of intellectual disability.PloS one · 2026Article
- A Sleeping Opportunity Does Not Restore Hippocampal Alterations Induced by 10 Days of Sleep Restriction in Rats.Neurochemical research · 2025Article
- Hippocampal dorsal CA1: Functional connectivity and role in HCN channelopathies in affective diseases and epilepsy.IBRO neuroscience reports · 2025Article
- The effect of traumatic brain injury on learning and memory: A synaptic focus.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025Review
- Different frequencies of human scalp-recorded theta activity may index integration of activity in distinct recurrent cortico-subcortical mnemonic networks.Frontiers in behavioral neuroscience · 2025Review
- Evolving alterations of structural organization and functional connectivity in feedforward neural networks after induced P301L tau mutation.The European journal of neuroscience · 2024Article
- ClScience advances · 2024Article
- Atrophy patterns in hippocampus and amygdala subregions of depressed patients with Parkinson's disease.Brain imaging and behavior · 2024Article
- Voltage-Gated NaLife (Basel, Switzerland) · 2023Review
- Atrophy asymmetry in hippocampal subfields in patients with Alzheimer's disease and mild cognitive impairment.Experimental brain research · 2023Article
- Deciphering the Effect of Different Genetic Variants on Hippocampal Subfield Volumes in the General Population.International journal of molecular sciences · 2023Article
- Resilience of Neural Cellularity to the Influence of Low Educational Level.Brain sciences · 2023Article
- Hippocampal glial inflammatory markers are differentially altered in a novel mouse model of perimenopausal cerebral amyloid angiopathy.Frontiers in aging neuroscience · 2023Article
- Stable wide-field voltage imaging for observing neuronal plasticity at the neuronal network level.Biophysics and physicobiology · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Decades of brain research have identified various parallel loops linking the hippocampus with neocortical areas, enabling the acquisition of spatial and episodic memories. Especially the hippocampal trisynaptic circuit [entorhinal cortex layer II → dentate gyrus (DG) → cornu ammonis (CA)-3 → CA1] was studied in great detail because of its seemingly simple connectivity and characteristic structures that are experimentally well accessible. While numerous researchers focused on functional aspects, obtained from a limited number of cells in distinct hippocampal subregions, little is known about the neuronal network dynamics which drive information across multiple synapses for subsequent long-term storage. Fast voltage-sensitive dye imaging in vitro allows real-time recording of activity patterns in large/meso-scale neuronal networks with high spatial resolution. In this way, we recently found that entorhinal theta-frequency input to the DG most effectively passes filter mechanisms of the trisynaptic circuit network, generating activity waves which propagate across the entire DG-CA axis. These "trisynaptic circuit waves" involve high-frequency firing of CA3 pyramidal neurons, leading to a rapid induction of classical NMDA receptor-dependent long-term potentiation (LTP) at CA3-CA1 synapses (CA1 LTP). CA1 LTP has been substantially evidenced to be essential for some forms of explicit learning in mammals. Here, we review data with particular reference to whole network-level approaches, illustrating how activity propagation can take place within the trisynaptic circuit to drive formation of CA1 LTP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.