ArticleFrontiers in neuroscience2015
Hypothalamic BOLD response to glucose intake and hypothalamic volume are similar in anorexia nervosa and healthy control subjects.
Article in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Common and distinct neural patterns of gray matter alterations in adults with anorexia nervosa and obsessive-compulsive disorder.European archives of psychiatry and clinical neuroscience · 2025Pooled it
- A meta-analytic investigation of grey matter differences in anorexia nervosa and autism spectrum disorder.European eating disorders review : the journal of the Eating Disorders Association · 2022Pooled it
- Structural and functional brain alterations in anorexia nervosa:A multimodal meta-analysis of neuroimaging studies.Human brain mapping · 2021Pooled it
- Brain morphological changes in adolescent and adult patients with anorexia nervosa.Journal of neural transmission (Vienna, Austria : 1996) · 2016Pooled it
- Brain and physiological responses to flavored waters with different sweeteners: a randomized crossover study in healthy young adults.The American journal of clinical nutrition · 2026Trial
- Neuroimaging of hypothalamic mechanisms related to glucose metabolism in anorexia nervosa and obesity.The Journal of clinical investigation · 2020Trial
- Common and sex-specific differences in hypothalamic subunit volumes and their links with depressive symptoms in treatment-naïve patients with major depressive disorder.Brain structure & function · 2025Article
- Challenges of Investigating Compartmentalized Brain Energy Metabolism Using Nuclear Magnetic Resonance Spectroscopy in vivo.Neurochemical research · 2025Review
- Mapping gray matter changes in anorexia nervosa: a functional connectivity network approach.Frontiers in nutrition · 2025Article
- The gut-brain axis in appetite, satiety, food intake, and eating behavior: Insights from animal models and human studies.Pharmacology research & perspectives · 2024Review
- Glucose-sensitive hypothalamic nuclei traced through functional magnetic resonance imaging.Frontiers in neuroscience · 2023Article
- A glucose-stimulated BOLD fMRI study of hypothalamic dysfunction in mice fed a high-fat and high-sucrose diet.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- The Role of the Human Hypothalamus in Food Intake Networks: An MRI Perspective.Frontiers in nutrition · 2021Review
- Psychoradiological investigations of gray matter alterations in patients with anorexia nervosa.Translational psychiatry · 2018Article
- Resting state hypothalamic response to glucose predicts glucose-induced attenuation in the ventral striatal response to food cues.Appetite · 2017Article
- Gray matter alterations and correlation of nutritional intake with the gray matter volume in prediabetes.Medicine · 2016Article
- Functional brain alterations in anorexia nervosa: a scoping review.Journal of eating disorders · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInconsistent findings about the neurobiology of Anorexia Nervosa (AN) hinder the development of effective treatments for this severe mental disorder. Therefore, the need arises for elucidation of neurobiological factors involved in the pathophysiology of AN. The hypothalamus plays a key role in the neurobiological processes that govern food intake and energy homeostasis, processes that are disturbed in anorexia nervosa (AN). The present study will assess the hypothalamic response to energy intake and the hypothalamic structure in patients with AN and healthy controls.
methodsTen women aged 18-30 years diagnosed with AN and 11 healthy, lean (BMI < 23 kg/m(2)) women in the same age range were recruited. We used functional magnetic resonance imaging (MRI) to determine function of the hypothalamus in response to glucose. Structural MRI was used to determine differences in hypothalamic volume and local gray matter volume using manual segmentation and voxel-based morphometry.
resultsNo differences were found in hypothalamic volume and neuronal activity in response to a glucose load between the patients and controls. Whole brain structural analysis showed a significant decrease in gray matter volume in the cingulate cortex in the AN patients, bilaterally.
conclusionsWe argue that in spite of various known changes in the hypothalamus the direct hypothalamic response to glucose intake is similar in AN patients and healthy controls.
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