ReviewFrontiers in neuroscience2015
Axonal activity in vivo: technical considerations and implications for the exploration of neural circuits in freely moving animals.
Review in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed.
- Laminar architecture of visual and auditory responses in the supplementary eye field of macaques.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Extracellular Spike Waveforms: Morphology, Biophysics, and Classification Strategies.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Population decoding of sound source location by receptive field neurons in the mouse superior colliculus.bioRxiv : the preprint server for biology · 2026Article
- Dynamics of excitability in axonal trees.Biophysical journal · 2026Article
- The central histaminergic system slows visual processing in the retina and lateral geniculate nucleus of awake mice.PLoS biology · 2025Article
- Brain stimulation preferentially influences long-range projections.Science advances · 2025Article
- Movement-related activity in the internal globus pallidus of the parkinsonian macaque.Journal of neurophysiology · 2025Article
- DREDge: robust motion correction for high-density extracellular recordings across species.Nature methods · 2025Article
- Variations of neuronal properties in the region of locus coeruleus of mice.Brain research · 2024Article
- Circuit dynamics of superficial and deep CA1 pyramidal cells and inhibitory cells in freely moving macaques.Cell reports · 2024Article
- Article
- The spiking output of the mouse olfactory bulb encodes large-scale temporal features of natural odor environments.bioRxiv : the preprint server for biology · 2024Article
- Circuit dynamics of superficial and deep CA1 pyramidal cells and inhibitory cells in freely-moving macaques.bioRxiv : the preprint server for biology · 2024Article
- More than expected: extracellular waveforms and functional responses in monkey LGN.bioRxiv : the preprint server for biology · 2024Article
- A sparse code for natural sound context in auditory cortex.Current research in neurobiology · 2024Article
- Article
- DREDge: robust motion correction for high-density extracellular recordings across species.bioRxiv : the preprint server for biology · 2023Article
- Isolating auditory-nerve contributions to electrocochleography by high-pass filtering: A better biomarker for cochlear nerve degeneration?JASA express letters · 2023Article
- Characterization of extracellular spike waveforms recorded in wallaby primary visual cortex.Frontiers in neuroscience · 2023Review
- Article
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Abstract
While extracellular somatic action potentials from freely moving rats have been well characterized, axonal activity has not. We have recently reported extracellular tetrode recordings of short duration waveforms (SDWs) with an average peak-trough duration less than 172 μs. These waveforms have significantly shorter duration than somatic action potentials and tend to be triphasic. The present review discusses further data that suggests SDWs are representative of axonal activity, how this characterization allows for more accurate classification of somatic activity and could serve as a means of exploring signal integration in neural circuits. The review also discusses how axons may function as more than neural cables and the implications this may have for axonal information processing. While the technical challenges necessary for the exploration of axonal processes in functional neural circuits during behavior are impressive, preliminary evidence suggests that the in vivo study of axons is attainable. The resulting theoretical implications for systems level function make refinement of this approach a necessary goal toward developing a more complete understanding of the processes underlying learning, memory and attention as well as the pathological states underlying mental illness and epilepsy.
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