ArticleInternational journal of biological sciences2015
Zebrafish Lbh-like Is Required for Otx2-mediated Photoreceptor Differentiation.
Article in International journal of biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Limb-bud and heart development (LBH) contributes to glioma progression in vitro and in vivo.FEBS open bio · 2022Article
- Human photoreceptor cells from different macular subregions have distinct transcriptional profiles.Human molecular genetics · 2021Article
- Transcription co-factor LBH is necessary for the survival of cochlear hair cells.Journal of cell science · 2021Article
- Different lineage contexts direct common pro-neural factors to specify distinct retinal cell subtypes.The Journal of cell biology · 2020Article
- Interphotoreceptor Retinoid-Binding Protein (IRBP) in Retinal Health and Disease.Frontiers in cellular neuroscience · 2020Review
- Overexpression of Limb-Bud and Heart (LBH) promotes angiogenesis in human glioma via VEGFA-mediated ERK signalling under hypoxia.EBioMedicine · 2019Article
- Divergence in larval jaw gene expression reflects differential trophic adaptation in haplochromine cichlids prior to foraging.BMC evolutionary biology · 2019Article
- Article
- Mechanisms of Photoreceptor Patterning in Vertebrates and Invertebrates.Trends in genetics : TIG · 2016Review
- Structure of zebrafish IRBP reveals fatty acid binding.Experimental eye research · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The homeobox transcription factor orthodenticle homolog 2 (otx2) is supposed as an organizer that orchestrates a transcription factor network during photoreceptor development. However, its regulation in the process remains unclear. In this study, we have identified a zebrafish limb bud and heart-like gene (lbh-like), which is expressed initially at 30 hours post fertilization (hpf) in the developing brain and eyes. Lbh-like knockdown by morpholinos specifically inhibits expression of multiple photoreceptor-specific genes, such as opsins, gnat1, gnat2 and irbp. Interestingly, otx2 expression in the morphants is not significantly reduced until 32 hpf when lbh-like begins to express, but its expression level in 72 hpf morphants is higher than that in wild type embryos. Co-injection of otx2 and its downstream target neuroD mRNAs can rescue the faults in eyes of Lbh-like morphants. Combined with the results of promoter-reporter assay, we suggest that lbh-like is a new regulator of photoreceptor differentiation directly through affecting otx2 expression in zebrafish. Furthermore, knockdown of lbh-like increases the activity of Notch pathway and perturbs the balance among proliferation, differentiation and survival of photoreceptor precursors.
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