Evidence map›Paper›PMID 25999743›Full record

ReviewStem cells and cloning : advances and applications2015

Cardiac tissue engineering and regeneration using cell-based therapy.

Mohammad T Alrefai, Divya Murali, Arghya Paul, Khalid M Ridwan, John M Connell, Dominique Shum-Tim

Open access · goldAbstract readReview
In one paragraph

Review in Stem cells and cloning : advances and applications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Heart-derived endogenous stem cells.Molecular biology reports · 2025
    Review
  4. Review
  5. Review
  6. Development of Novel 3D Spheroids for Discrete Subaortic Stenosis.Cardiovascular engineering and technology · 2024
    Article
  7. Article
  8. Cell Therapy in the Treatment of Coronary Heart Disease.International journal of molecular sciences · 2023
    Review
  9. Review
  10. Genome Editing and Cardiac Regeneration.Advances in experimental medicine and biology · 2023
    Article
  11. Latest Advances in 3D Bioprinting of Cardiac Tissues.Advanced materials technologies · 2022
    Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Mohammad T AlrefaiDivision of Cardiac Surgery, McGill University Health Center, Montreal, QC, Canada ; Division of Surgical Research, McGill University Health Center, Montreal, QC, Canada ; King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
Divya MuraliDepartment of Chemical and Petroleum Engineering, School of Engineering, University of Kansas, Lawrence, KS, USA.
Arghya PaulDepartment of Chemical and Petroleum Engineering, School of Engineering, University of Kansas, Lawrence, KS, USA.
Khalid M RidwanDivision of Cardiac Surgery, McGill University Health Center, Montreal, QC, Canada ; Division of Surgical Research, McGill University Health Center, Montreal, QC, Canada.
John M ConnellDivision of Cardiac Surgery, McGill University Health Center, Montreal, QC, Canada ; Division of Surgical Research, McGill University Health Center, Montreal, QC, Canada.
Dominique Shum-TimDivision of Cardiac Surgery, McGill University Health Center, Montreal, QC, Canada ; Division of Surgical Research, McGill University Health Center, Montreal, QC, Canada.
McGill University Health Centre · CAUniversity of Kansas · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stem cell therapy and tissue engineering represent a forefront of current research in the treatment of heart disease. With these technologies, advancements are being made into therapies for acute ischemic myocardial injury and chronic, otherwise nonreversible, myocardial failure. The current clinical management of cardiac ischemia deals with reestablishing perfusion to the heart but not dealing with the irreversible damage caused by the occlusion or stenosis of the supplying vessels. The applications of these new technologies are not yet fully established as part of the management of cardiac diseases but will become so in the near future. The discussion presented here reviews some of the pioneering works at this new frontier. Key results of allogeneic and autologous stem cell trials are presented, including the use of embryonic, bone marrow-derived, adipose-derived, and resident cardiac stem cells.

Indexed as

cardiac surgerycardiomyocytescell sheet and tissue engineeringheartheart failuremyocardial ischemiaorganoidsscaffoldsstem cells

Identifiers

PMID25999743
PMCPMC4437607
OpenAlexW2123023378

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.