ArticleInternational journal of nanomedicine2015
Amalgamation of complex iron(III) ions and iron nanoclusters with MWCNTs as a route to potential T2 MRI contrast agents.
Article in International journal of nanomedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Oxygen Functional Groups on MWCNT Surface as Critical Factor BoostingInternational journal of nanomedicine · 2020Article
- A dual-mode nanoparticle based on natural biomaterials for photoacoustic and magnetic resonance imaging of bone mesenchymal stem cellsRSC advances · 2019Article
- Carbon Nano-Allotrope/Magnetic Nanoparticle Hybrid Nanomaterials as T2 Contrast Agents for Magnetic Resonance Imaging Applications.Journal of functional biomaterials · 2018Review
- A comparison of immunotoxic effects of nanomedicinal products with regulatory immunotoxicity testing requirements.International journal of nanomedicine · 2016Review
- Multiwalled carbon nanotube hybrids as MRI contrast agents.Beilstein journal of nanotechnology · 2016Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron-filled multiwall carbon nanotubes (Fe@MWCNTs) were functionalized toward a variety of potential magnetic resonance imaging contrast agents. Oxidized Fe@MWNCTs were covered with PEG5000 via direct esterification or using acyl chloride derivatives. Alternatively, the latter were functionalized with an aminophenol ligand (Fe@O-MWCNT-L). Moreover, pristine Fe@MWCNTs were functionalized with N-phenylaziridine groups (Fe@f-MWCNT) via [2+1] cycloaddition of nitrene. All of these chemically modified nanotubes served as a vehicle for anchoring Fe(3+) ions. The new hybrids--Fe(III)/Fe@(f-/O-)MWCNTs--containing 6%-14% of the "tethered" Fe(3+) ions were studied in terms of the acceleration of relaxation of water protons in nuclear magnetic resonance. The highest transverse relaxivity r2=63.9±0.9 mL mg(-1) s(-1) was recorded for Fe(III)/Fe@O-MWCNT-L, while for Fe(III)/Fe@f-MWCNT, with r2=57.9±2.9 mL mg(-1) s(-1), the highest impact of the anchored Fe(III) ions was observed. The T1/T2 ratio of 30-100 found for all of the nanotube hybrids presented in this work is a very important factor for their potential application as T2 contrast agents. Increased stability of the hybrids was confirmed by ultraviolet-visible spectrophotometry.
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Registered trials
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