ReviewInternational journal of nanomedicine2015
Application of dental nanomaterials: potential toxicity to the central nervous system.
Review in International journal of nanomedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Physicochemical, mechanical and biological properties of nano-calcium silicate-based cements: a systematic review.Odontology · 2023Pooled it
- Applications of Nanomaterials in Restorative Dentistry and Endodontics: A Narrative Review.Materials (Basel, Switzerland) · 2026Review
- Advancements in nanohydroxyapatite: synthesis, biomedical applications and composite developments.Regenerative biomaterials · 2025Review
- Advances in Bioceramics for Bone Regeneration: A Narrative Review.Biomimetics (Basel, Switzerland) · 2024Review
- Patient Centricity-An Empirical Research on Titanium Dental Implants and Their Adverse Effects on Health Condition.Healthcare (Basel, Switzerland) · 2024Article
- Research hotspots and trends of nanomaterials in stomatology: A bibliometric analysis from 2000 to 2023.Heliyon · 2024Article
- Improved Method for Electron Powder Diffraction-Based Rietveld Analysis of Nanomaterials.Nanomaterials (Basel, Switzerland) · 2024Article
- Long-term application of silver nanoparticles in dental restoration materials: potential toxic injury to the CNS.Journal of materials science. Materials in medicine · 2023Review
- Smart dental materials for antimicrobial applications.Bioactive materials · 2023Article
- Expression of Interleukin-1β and Histological Changes of the Three-Dimensional Oral Mucosal Model in Response to Yttria-Stabilized Nanozirconia.Materials (Basel, Switzerland) · 2023Article
- Gelatin-Curcumin Nanocomposites as a Coating for Implant Healing Abutment: In Vitro Stability Investigation.Clinics and practice · 2023Article
- Oxidative stress and apoptotic index modifications in the hippocampus of rat pups born to mothers exposed to buprenorphine during lactation.Toxicology reports · 2022Article
- Titanium Dioxide, but Not Zinc Oxide, Nanoparticles Cause Severe Transcriptomic Alterations in T98G Human Glioblastoma Cells.International journal of molecular sciences · 2021Article
- Nanomaterials Application in Orthodontics.Nanomaterials (Basel, Switzerland) · 2021Review
- A Carrier-Free Folate Receptor-Targeted Ursolic Acid/Methotrexate Nanodelivery System for Synergetic Anticancer Therapy.International journal of nanomedicine · 2021Article
- Nanotechnology in dentistry: Present and future perspectives on dental nanomaterials.Dental materials : official publication of the Academy of Dental Materials · 2020Review
- Emerging Nanotechnology in Non-Surgical Periodontal Therapy in Animal Models: A Systematic Review.Nanomaterials (Basel, Switzerland) · 2020Review
- Applications of nano-materials in diverse dentistry regimes.RSC advances · 2020Review
- Nanotechnology Scaffolds for Alveolar Bone Regeneration.Materials (Basel, Switzerland) · 2020Review
- Local Cellular Responses to Metallic and Ceramic Nanoparticles from Orthopedic Joint Arthroplasty Implants.International journal of nanomedicine · 2020Review
Corrections and comments
- Commented on by
- Commented on byAuthors' reply.2015
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanomaterials are defined as materials with one or more external dimensions with a size of 1-100 nm. Such materials possess typical nanostructure-dependent properties (eg, chemical, biological, optical, mechanical, and magnetic), which may differ greatly from the properties of their bulk counterparts. In recent years, nanomaterials have been widely used in the production of dental materials, particularly in light polymerization composite resins and bonding systems, coating materials for dental implants, bioceramics, endodontic sealers, and mouthwashes. However, the dental applications of nanomaterials yield not only a significant improvement in clinical treatments but also growing concerns regarding their biosecurity. The brain is well protected by the blood-brain barrier (BBB), which separates the blood from the cerebral parenchyma. However, in recent years, many studies have found that nanoparticles (NPs), including nanocarriers, can transport through the BBB and locate in the central nervous system (CNS). Because the CNS may be a potential target organ of the nanomaterials, it is essential to determine the neurotoxic effects of NPs. In this review, possible dental nanomaterials and their pathways into the CNS are discussed, as well as related neurotoxicity effects underlying the in vitro and in vivo studies. Finally, we analyze the limitations of the current testing methods on the toxicological effects of nanomaterials. This review contributes to a better understanding of the nano-related risks to the CNS as well as the further development of safety assessment systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.