Evidence map›Paper›PMID 25999512›Full record

ReviewScience (New York, N.Y.)2015

Innate lymphoid cells. Innate lymphoid cells: a new paradigm in immunology.

Gérard Eberl, Marco Colonna, James P Di Santo, Andrew N J McKenzie

Open access · greenAbstract readReview
In one paragraph

Review in Science (New York, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 501 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
501citing papers in PubMed, 2 pooled it
36.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

501 citing papers in PubMed, 2 syntheses or guidelines pooled it, 834 citations in OpenAlex.

  1. Myocardial Immune Cells: The Basis of Cardiac Immunology.Journal of immunology (Baltimore, Md. : 1950) · 2023
    Pooled it
  2. Pooled it
  3. Article
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  5. Priming of CD8Nature neuroscience · 2026
    Article
  6. Erythromycin inhibits the differentiation of NCRJournal of thoracic disease · 2026
    Article
  7. Article
  8. Innate immunity: current understandings and future perspectives.Signal transduction and targeted therapy · 2026
    Review
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  11. Article
  12. Article
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441 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Gérard EberlInstitut Pasteur, Microenvironment and Immunity Unit, 75724 Paris, France. gerard.eberl@pasteur.fr.
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
James P Di SantoInstitut Pasteur, Innate Immunity Unit, INSERM U668, 75724 Paris, France.
Andrew N J McKenzieMedical Research Council (MRC) Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
Institut Pasteur · FRMRC Laboratory of Molecular Biology · GBWashington University in St. Louis · US

Funding

Mucosal Immune Defense Mechanisms of the Urinary BladderU01AI095542 · NIAID · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, HULTGREN, SCOTT J. · 2011 to 2020
$9.8M
THE ROLE OF NK-22 CELLS IN ANTI-HIV-1 MUCOSAL IMMUNITYR01DE021255 · NIDCR · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2010 to 2014
$1.9M
CONTROLLING NK CELL ANTI-CANCER ACTIVITY: THE ROLE OF NUTRIENTS AND SUPPLEMENTSR21CA167192 · NCI · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2013 to 2014
$358k
Medical Research Council MC_U105178805NCI NIH HHS R21CA16719NCI NIH HHS R21 CA167192NIAID NIH HHS 1U01AI095542NIAID NIH HHS U01 AI095542NIDCR NIH HHS R01 DE021255NIDCR NIH HHS R01DE021255Wellcome Trust 100963
6 · The paper itself

Abstract

Innate lymphoid cells (ILCs) are a growing family of immune cells that mirror the phenotypes and functions of T cells. However, in contrast to T cells, ILCs do not express acquired antigen receptors or undergo clonal selection and expansion when stimulated. Instead, ILCs react promptly to signals from infected or injured tissues and produce an array of secreted proteins termed cytokines that direct the developing immune response into one that is adapted to the original insult. The complex cross-talk between microenvironment, ILCs, and adaptive immunity remains to be fully deciphered. Only by understanding these complex regulatory networks can the power of ILCs be controlled or unleashed in order to regulate or enhance immune responses in disease prevention and therapy.

Indexed as

Biological EvolutionImmunity, InnateAdaptive ImmunityAdipose TissueBone MarrowCytokinesDietHumansImmunotherapyInflammationLiverLymphocyte ActivationLymphocytesMicrobiotaT-LymphocytesCytokines

Identifiers

PMID25999512
PMCPMC5658207
OpenAlexW1608909099

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.