ArticlePlant physiology2015
Evolutionary Dynamics of the Cellulose Synthase Gene Superfamily in Grasses.
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Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37citing papers in PubMed
8.8field-weighted citation impact, top 3% of its field
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37 citing papers in PubMed, 56 citations in OpenAlex.
- Diversification of Cellulose Synthase (CESA) Genes in Mosses Suggests Both Ancient and Recent Gene duplications.Journal of molecular evolution · 2026Article
- Genome-wide identification, characterization and expression analysis of the CesA/Csl superfamily in Boehmeria nivea and its feral species.BMC plant biology · 2026Article
- The knockout of ClaCSLH1 induced dwarfing in watermelon.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- ExploringGenes · 2024Article
- Enzymes in 3D: Synthesis, remodelling, and hydrolysis of cell wall (1,3;1,4)-β-glucans.Plant physiology · 2023Article
- Highly differentiated genomic properties underpin the different cell walls of Poaceae and eudicots.Plant physiology · 2023Article
- Genetic Approaches to Increase Arabinoxylan and β-Glucan Content in Wheat.Plants (Basel, Switzerland) · 2023Review
- The Gram-positive bacterium Romboutsia ilealis harbors a polysaccharide synthase that can produce (1,3;1,4)-β-D-glucans.Nature communications · 2023Article
- Unraveling the Potential of β-D-Glucans inLife (Basel, Switzerland) · 2023Review
- Identification and bioinformatic analysis of the CaCesA/Csls family members and the expression of the CaCslD1 in the flower buds of CMS/Rf system in pepper.Functional & integrative genomics · 2022Article
- Mechanism of mixed-linkage glucan biosynthesis by barley cellulose synthase-like CslF6 (1,3;1,4)-β-glucan synthase.Science advances · 2022Article
- Study of Dynamic Accumulation in β-D-Glucan in Oat (Polymers · 2022Article
- The cellulose synthase-like F3 (CslF3) gene mediates cell wall polysaccharide synthesis and affects root growth and differentiation in barley.The Plant journal : for cell and molecular biology · 2022Article
- Genome-wide bioinformatics analysis of Cellulose Synthase gene family in common bean (Phaseolus vulgaris L.) and the expression in the pod development.BMC genomic data · 2022Article
- Genomic Architecture and Evolution of theFrontiers in plant science · 2022Article
- Species-Specific Gene Expansion of theFrontiers in plant science · 2022Article
- QTL mapping and candidate gene mining of flag leaf size traits in Japonica rice based on linkage mapping and genome-wide association study.Molecular biology reports · 2022Article
- Updating Insights into the Catalytic Domain Properties of PlantMolecules (Basel, Switzerland) · 2021Review
- Genome-Wide Association Mapping of Mixed Linkage (1,3;1,4)-β-Glucan and Starch Contents in Rice Whole Grain.Frontiers in plant science · 2021Article
- Genome-wide characterization of the cellulose synthase gene superfamily in Pyrus bretschneideri and reveal its potential role in stone cell formation.Functional & integrative genomics · 2020Article
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Authors and funding
14 authors at 2 institutions in 4 countries.
Julian G SchwerdtAustralian Research Council Centre of Excellence in Plant Cell Walls, University of Adelaide, Waite Campus, Glen Osmond, South Australia 5064, Australia (J.G.S., N.J.S., R.A.B., G.B.F.);Biomathematics and Statistics Scotland, Invergowrie, Dundee DD2 5DA United Kingdom (K.M., F.W);IBM Research Collaboratory for Life Sciences, University of Melbourne, Parkville, Victoria 3053, Australia (D.O., J.M.W.);Department of Genetics and Bioengineering, Yeditepe University, Kayisdagi, Istanbul 34755, Turkey (A.J.H.);Division of Plant Sciences, University of Dundee at the James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (M.S., C.H., R.W.);University of Virginia, School of Medicine, Charlottesville, Virginia 22908 (J.Z.); andJames Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (D.F.M., R.W.).
Katrin MacKenzieAustralian Research Council Centre of Excellence in Plant Cell Walls, University of Adelaide, Waite Campus, Glen Osmond, South Australia 5064, Australia (J.G.S., N.J.S., R.A.B., G.B.F.);Biomathematics and Statistics Scotland, Invergowrie, Dundee DD2 5DA United Kingdom (K.M., F.W);IBM Research Collaboratory for Life Sciences, University of Melbourne, Parkville, Victoria 3053, Australia (D.O., J.M.W.);Department of Genetics and Bioengineering, Yeditepe University, Kayisdagi, Istanbul 34755, Turkey (A.J.H.);Division of Plant Sciences, University of Dundee at the James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (M.S., C.H., R.W.);University of Virginia, School of Medicine, Charlottesville, Virginia 22908 (J.Z.); andJames Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (D.F.M., R.W.).ORCID http://orcid.org/0000-0002-9567-1856
Frank WrightAustralian Research Council Centre of Excellence in Plant Cell Walls, University of Adelaide, Waite Campus, Glen Osmond, South Australia 5064, Australia (J.G.S., N.J.S., R.A.B., G.B.F.);Biomathematics and Statistics Scotland, Invergowrie, Dundee DD2 5DA United Kingdom (K.M., F.W);IBM Research Collaboratory for Life Sciences, University of Melbourne, Parkville, Victoria 3053, Australia (D.O., J.M.W.);Department of Genetics and Bioengineering, Yeditepe University, Kayisdagi, Istanbul 34755, Turkey (A.J.H.);Division of Plant Sciences, University of Dundee at the James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (M.S., C.H., R.W.);University of Virginia, School of Medicine, Charlottesville, Virginia 22908 (J.Z.); andJames Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (D.F.M., R.W.).
Daniel OehmeAustralian Research Council Centre of Excellence in Plant Cell Walls, University of Adelaide, Waite Campus, Glen Osmond, South Australia 5064, Australia (J.G.S., N.J.S., R.A.B., G.B.F.);Biomathematics and Statistics Scotland, Invergowrie, Dundee DD2 5DA United Kingdom (K.M., F.W);IBM Research Collaboratory for Life Sciences, University of Melbourne, Parkville, Victoria 3053, Australia (D.O., J.M.W.);Department of Genetics and Bioengineering, Yeditepe University, Kayisdagi, Istanbul 34755, Turkey (A.J.H.);Division of Plant Sciences, University of Dundee at the James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (M.S., C.H., R.W.);University of Virginia, School of Medicine, Charlottesville, Virginia 22908 (J.Z.); andJames Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (D.F.M., R.W.).
John M WagnerAustralian Research Council Centre of Excellence in Plant Cell Walls, University of Adelaide, Waite Campus, Glen Osmond, South Australia 5064, Australia (J.G.S., N.J.S., R.A.B., G.B.F.);Biomathematics and Statistics Scotland, Invergowrie, Dundee DD2 5DA United Kingdom (K.M., F.W);IBM Research Collaboratory for Life Sciences, University of Melbourne, Parkville, Victoria 3053, Australia (D.O., J.M.W.);Department of Genetics and Bioengineering, Yeditepe University, Kayisdagi, Istanbul 34755, Turkey (A.J.H.);Division of Plant Sciences, University of Dundee at the James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (M.S., C.H., R.W.);University of Virginia, School of Medicine, Charlottesville, Virginia 22908 (J.Z.); andJames Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (D.F.M., R.W.).
Andrew J HarveyAustralian Research Council Centre of Excellence in Plant Cell Walls, University of Adelaide, Waite Campus, Glen Osmond, South Australia 5064, Australia (J.G.S., N.J.S., R.A.B., G.B.F.);Biomathematics and Statistics Scotland, Invergowrie, Dundee DD2 5DA United Kingdom (K.M., F.W);IBM Research Collaboratory for Life Sciences, University of Melbourne, Parkville, Victoria 3053, Australia (D.O., J.M.W.);Department of Genetics and Bioengineering, Yeditepe University, Kayisdagi, Istanbul 34755, Turkey (A.J.H.);Division of Plant Sciences, University of Dundee at the James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (M.S., C.H., R.W.);University of Virginia, School of Medicine, Charlottesville, Virginia 22908 (J.Z.); andJames Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (D.F.M., R.W.).ORCID http://orcid.org/0000-0002-3488-0531
Neil J ShirleyAustralian Research Council Centre of Excellence in Plant Cell Walls, University of Adelaide, Waite Campus, Glen Osmond, South Australia 5064, Australia (J.G.S., N.J.S., R.A.B., G.B.F.);Biomathematics and Statistics Scotland, Invergowrie, Dundee DD2 5DA United Kingdom (K.M., F.W);IBM Research Collaboratory for Life Sciences, University of Melbourne, Parkville, Victoria 3053, Australia (D.O., J.M.W.);Department of Genetics and Bioengineering, Yeditepe University, Kayisdagi, Istanbul 34755, Turkey (A.J.H.);Division of Plant Sciences, University of Dundee at the James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (M.S., C.H., R.W.);University of Virginia, School of Medicine, Charlottesville, Virginia 22908 (J.Z.); andJames Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (D.F.M., R.W.).
Rachel A BurtonAustralian Research Council Centre of Excellence in Plant Cell Walls, University of Adelaide, Waite Campus, Glen Osmond, South Australia 5064, Australia (J.G.S., N.J.S., R.A.B., G.B.F.);Biomathematics and Statistics Scotland, Invergowrie, Dundee DD2 5DA United Kingdom (K.M., F.W);IBM Research Collaboratory for Life Sciences, University of Melbourne, Parkville, Victoria 3053, Australia (D.O., J.M.W.);Department of Genetics and Bioengineering, Yeditepe University, Kayisdagi, Istanbul 34755, Turkey (A.J.H.);Division of Plant Sciences, University of Dundee at the James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (M.S., C.H., R.W.);University of Virginia, School of Medicine, Charlottesville, Virginia 22908 (J.Z.); andJames Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (D.F.M., R.W.).
Miriam SchreiberAustralian Research Council Centre of Excellence in Plant Cell Walls, University of Adelaide, Waite Campus, Glen Osmond, South Australia 5064, Australia (J.G.S., N.J.S., R.A.B., G.B.F.);Biomathematics and Statistics Scotland, Invergowrie, Dundee DD2 5DA United Kingdom (K.M., F.W);IBM Research Collaboratory for Life Sciences, University of Melbourne, Parkville, Victoria 3053, Australia (D.O., J.M.W.);Department of Genetics and Bioengineering, Yeditepe University, Kayisdagi, Istanbul 34755, Turkey (A.J.H.);Division of Plant Sciences, University of Dundee at the James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (M.S., C.H., R.W.);University of Virginia, School of Medicine, Charlottesville, Virginia 22908 (J.Z.); andJames Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (D.F.M., R.W.).
Claire HalpinAustralian Research Council Centre of Excellence in Plant Cell Walls, University of Adelaide, Waite Campus, Glen Osmond, South Australia 5064, Australia (J.G.S., N.J.S., R.A.B., G.B.F.);Biomathematics and Statistics Scotland, Invergowrie, Dundee DD2 5DA United Kingdom (K.M., F.W);IBM Research Collaboratory for Life Sciences, University of Melbourne, Parkville, Victoria 3053, Australia (D.O., J.M.W.);Department of Genetics and Bioengineering, Yeditepe University, Kayisdagi, Istanbul 34755, Turkey (A.J.H.);Division of Plant Sciences, University of Dundee at the James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (M.S., C.H., R.W.);University of Virginia, School of Medicine, Charlottesville, Virginia 22908 (J.Z.); andJames Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (D.F.M., R.W.).ORCID http://orcid.org/0000-0002-1808-8130
Jochen ZimmerAustralian Research Council Centre of Excellence in Plant Cell Walls, University of Adelaide, Waite Campus, Glen Osmond, South Australia 5064, Australia (J.G.S., N.J.S., R.A.B., G.B.F.);Biomathematics and Statistics Scotland, Invergowrie, Dundee DD2 5DA United Kingdom (K.M., F.W);IBM Research Collaboratory for Life Sciences, University of Melbourne, Parkville, Victoria 3053, Australia (D.O., J.M.W.);Department of Genetics and Bioengineering, Yeditepe University, Kayisdagi, Istanbul 34755, Turkey (A.J.H.);Division of Plant Sciences, University of Dundee at the James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (M.S., C.H., R.W.);University of Virginia, School of Medicine, Charlottesville, Virginia 22908 (J.Z.); andJames Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (D.F.M., R.W.).
David F MarshallAustralian Research Council Centre of Excellence in Plant Cell Walls, University of Adelaide, Waite Campus, Glen Osmond, South Australia 5064, Australia (J.G.S., N.J.S., R.A.B., G.B.F.);Biomathematics and Statistics Scotland, Invergowrie, Dundee DD2 5DA United Kingdom (K.M., F.W);IBM Research Collaboratory for Life Sciences, University of Melbourne, Parkville, Victoria 3053, Australia (D.O., J.M.W.);Department of Genetics and Bioengineering, Yeditepe University, Kayisdagi, Istanbul 34755, Turkey (A.J.H.);Division of Plant Sciences, University of Dundee at the James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (M.S., C.H., R.W.);University of Virginia, School of Medicine, Charlottesville, Virginia 22908 (J.Z.); andJames Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (D.F.M., R.W.).
Robbie WaughAustralian Research Council Centre of Excellence in Plant Cell Walls, University of Adelaide, Waite Campus, Glen Osmond, South Australia 5064, Australia (J.G.S., N.J.S., R.A.B., G.B.F.);Biomathematics and Statistics Scotland, Invergowrie, Dundee DD2 5DA United Kingdom (K.M., F.W);IBM Research Collaboratory for Life Sciences, University of Melbourne, Parkville, Victoria 3053, Australia (D.O., J.M.W.);Department of Genetics and Bioengineering, Yeditepe University, Kayisdagi, Istanbul 34755, Turkey (A.J.H.);Division of Plant Sciences, University of Dundee at the James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (M.S., C.H., R.W.);University of Virginia, School of Medicine, Charlottesville, Virginia 22908 (J.Z.); andJames Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (D.F.M., R.W.).
Geoffrey B FincherAustralian Research Council Centre of Excellence in Plant Cell Walls, University of Adelaide, Waite Campus, Glen Osmond, South Australia 5064, Australia (J.G.S., N.J.S., R.A.B., G.B.F.);Biomathematics and Statistics Scotland, Invergowrie, Dundee DD2 5DA United Kingdom (K.M., F.W);IBM Research Collaboratory for Life Sciences, University of Melbourne, Parkville, Victoria 3053, Australia (D.O., J.M.W.);Department of Genetics and Bioengineering, Yeditepe University, Kayisdagi, Istanbul 34755, Turkey (A.J.H.);Division of Plant Sciences, University of Dundee at the James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (M.S., C.H., R.W.);University of Virginia, School of Medicine, Charlottesville, Virginia 22908 (J.Z.); andJames Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (D.F.M., R.W.) geoff.fincher@adelaide.edu.au.
Australian Research Council · AUYeditepe University · TR
Funding
Biotechnology and Biological Sciences Research Council BB/G016232/1
Abstract
Phylogenetic analyses of cellulose synthase (CesA) and cellulose synthase-like (Csl) families from the cellulose synthase gene superfamily were used to reconstruct their evolutionary origins and selection histories. Counterintuitively, genes encoding primary cell wall CesAs have undergone extensive expansion and diversification following an ancestral duplication from a secondary cell wall-associated CesA. Selection pressure across entire CesA and Csl clades appears to be low, but this conceals considerable variation within individual clades. Genes in the CslF clade are of particular interest because some mediate the synthesis of (1,3;1,4)-β-glucan, a polysaccharide characteristic of the evolutionarily successful grasses that is not widely distributed elsewhere in the plant kingdom. The phylogeny suggests that duplication of either CslF6 and/or CslF7 produced the ancestor of a highly conserved cluster of CslF genes that remain located in syntenic regions of all the grass genomes examined. A CslF6-specific insert encoding approximately 55 amino acid residues has subsequently been incorporated into the gene, or possibly lost from other CslFs, and the CslF7 clade has undergone a significant long-term shift in selection pressure. Homology modeling and molecular dynamics of the CslF6 protein were used to define the three-dimensional dispositions of individual amino acids that are subject to strong ongoing selection, together with the position of the conserved 55-amino acid insert that is known to influence the amounts and fine structures of (1,3;1,4)-β-glucans synthesized. These wall polysaccharides are attracting renewed interest because of their central roles as sources of dietary fiber in human health and for the generation of renewable liquid biofuels.
Indexed as
Evolution, MolecularGenes, PlantMultigene FamilyAmino AcidsAmino Acid SubstitutionChromosomes, PlantConserved SequenceGlucosyltransferasesModels, MolecularPhylogenyPoaceaeSelection, GeneticStructural Homology, ProteinAmino Acidscellulose synthaseGlucosyltransferases
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