Evidence map›Paper›PMID 25999401›Full record

Trial reportJournal of the American Heart Association2015

Catheter Ablation of Atrial Fibrillation in U.S. Community Practice--Results From Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF).

Fredrik Holmqvist, DaJuanicia Simon, Benjamin A Steinberg, Seok Jae Hong, Peter R Kowey, James A Reiffel, Gerald V Naccarelli, Paul Chang, Bernard J Gersh, Eric D Peterson and 2 more

Registry-linked trialOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01165710 (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01165710 completednot on this map

Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF)

TypeobservationalSponsorJanssen Scientific Affairs, LLCRan2010 to 2014Enrolled10,179ConditionsAtrial FibrillationArmsPatients with Atrial Fibrillation (AF)
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 35 citations in OpenAlex.

  1. Effect of repeat catheter ablation vs. antiarrhythmic drug therapy among patients with recurrent atrial tachycardia/atrial fibrillation after atrial fibrillation catheter ablation: data from CHINA-AF registry.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Review
  7. Observational
  8. Article
  9. Article
  10. Sleep Apnea Is a Risk Factor for Stroke and Vascular Dementia.Current neurology and neuroscience reports · 2018
    Review
  11. Article
  12. [Electrophysiologic procedure complications in the elderly].Herzschrittmachertherapie & Elektrophysiologie · 2017
    Review
  13. Sleep apnoea and stroke.Stroke and vascular neurology · 2016
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Fredrik HolmqvistDuke Clinical Research Institute, Durham, NC (F.H., D.J.S., B.A.S., S.J.H., E.D.P., J.P.P.).
DaJuanicia SimonDuke Clinical Research Institute, Durham, NC (F.H., D.J.S., B.A.S., S.J.H., E.D.P., J.P.P.).
Benjamin A SteinbergDuke Clinical Research Institute, Durham, NC (F.H., D.J.S., B.A.S., S.J.H., E.D.P., J.P.P.).
Seok Jae HongDuke Clinical Research Institute, Durham, NC (F.H., D.J.S., B.A.S., S.J.H., E.D.P., J.P.P.).
Peter R KoweyLankenau Hospital and Medical Research Center, Philadelphia, PA (P.R.K.).
James A ReiffelColumbia University, New York, NY (J.A.R.).
Gerald V NaccarelliPenn State Milton S. Hershey Medical Center, Hershey, PA (G.V.N.).
Paul ChangJanssen Pharmaceuticals, Inc, Raritan, NJ (P.C.).
Bernard J GershMayo Clinic College of Medicine, Rochester, MN (B.J.G.).
Eric D PetersonDuke Clinical Research Institute, Durham, NC (F.H., D.J.S., B.A.S., S.J.H., E.D.P., J.P.P.).
Jonathan P PicciniDuke Clinical Research Institute, Durham, NC (F.H., D.J.S., B.A.S., S.J.H., E.D.P., J.P.P.).
ORBIT‐AF Investigators
Clinical Research Institute · USColumbia University · USJanssen (Belgium) · BELankenau Medical Center · USMayo Clinic · USPenn State Milton S. Hershey Medical Center · US

Funding

Using Data to Drive Change in National CV Care: The Duke CERTSU19HS021092 · AHRQ · DUKE UNIVERSITY · PI PETERSON, ERIC DAVID · 2011 to 2015
$4.2M
AHRQ HHS 1U19 HS021092.
6 · The paper itself

Abstract

backgroundThe characteristics of patients undergoing atrial fibrillation (AF) ablation and subsequent outcomes in community practice are not well described. METHODS AND

resultsUsing the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF), we investigated the prevalence and impact of catheter ablation of AF. Among 9935 patients enrolled, 5.3% had previous AF ablation. Patients with AF ablation were significantly younger, more frequently male, and had less anemia, chronic obstructive pulmonary disease, and previous myocardial infarction (P<0.05 for all analyses) than those without previous catheter ablation of AF. Ablated patients were more likely to have a family history of AF, obstructive sleep apnea, paroxysmal AF, and moderate-to-severe symptoms (P<0.0001 for all analyses). Patients with previous ablation were more often in sinus rhythm on entry into the registry (52% vs. 32%; P<0.0001). Despite previous ablation, 46% in the ablation group were still on antiarrhythmic therapy. Oral anticoagulation was prescribed in 75% of those with previous ablation versus 76% in those without previous ablation (P=0.5). The adjusted risk of death (hazard ratio [HR], 0.78; 95% confidence interval [CI], 0.52 to 1.18; P=0.2) and cardiovascular (CV) hospitalization (HR, 1.06; 95% CI, 0.90 to 1.26; P=0.5) were similar in both groups. Patients with incident AF ablation had higher risk of subsequent CV hospitalization than matched patients without incident ablation (HR, 1.67; 95% CI, 1.24 to 2.26; P=0.0008).

conclusionsIn U.S. clinical practice, a minority of patients with AF are managed with catheter ablation. Subsequent to ablation, there were no significant differences in oral anticoagulation use or outcomes, including stroke/non-central nervous system embolism/transient ischemic attack or death. CLINICAL

trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01165710.

Indexed as

Hospitals, CommunityAgedAnticoagulantsAtrial FibrillationCatheter AblationFemaleHospitalizationHumansMaleMiddle AgedRegistriesRisk FactorsTreatment OutcomeUnited StatesAnticoagulantsanticoagulantsatrial fibrillationcatheter ablationmorbiditysurvival

Identifiers

PMID25999401
PMCPMC4599417
OpenAlexW2095746541

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.