Evidence map›Paper›PMID 25999400›Full record

ArticleJournal of the American Heart Association2015

Racial differences in circulating natriuretic peptide levels: the atherosclerosis risk in communities study.

Deepak K Gupta, Brian Claggett, Quinn Wells, Susan Cheng, Man Li, Nisa Maruthur, Elizabeth Selvin, Josef Coresh, Suma Konety, Kenneth R Butler and 5 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02730780 (The Natriuretic Peptide System in African-Americans.), which is not on this map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02730780 nacompletednot on this mapstarted 2016, after this paper: background citation

The Natriuretic Peptide System in African-Americans.

TypeinterventionalSponsorVanderbilt UniversityRan2016 to 2021Enrolled60ConditionsHealthy, PrehypertensionArmsLow-Salt Diet, High-Salt Diet
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 76 citations in OpenAlex.

  1. Trial
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  5. Effect of Testosterone on Natriuretic Peptide Levels.Journal of the American College of Cardiology · 2019
    Trial
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  7. Circulating Cardiovascular Proteomic Associations With Genetics and Disease.Circulation. Genomic and precision medicine · 2025
    Article
  8. Article
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  12. Sex-based differences in metabolic protection by the ANP genetic variant rs5068 in the general population.American journal of physiology. Heart and circulatory physiology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 1 country.

Deepak K GuptaVanderbilt Heart and Vascular Institute, Vanderbilt University Medical Center, Nashville, TN (D.K.G., Q.W.).
Brian ClaggettBrigham and Women's Hospital, Harvard Medical School, Boston, MA (B.C., S.C., S.D.S.).
Quinn WellsVanderbilt Heart and Vascular Institute, Vanderbilt University Medical Center, Nashville, TN (D.K.G., Q.W.).
Susan ChengBrigham and Women's Hospital, Harvard Medical School, Boston, MA (B.C., S.C., S.D.S.).
Man LiDepartment of Epidemiology, Johns Hopkins University, Baltimore, MD (M.L., E.S., J.C.).
Nisa MaruthurDepartment of Medicine, Johns Hopkins University, Baltimore, MD (N.M., E.S.).
Elizabeth SelvinDepartment of Epidemiology, Johns Hopkins University, Baltimore, MD (M.L., E.S., J.C.) Department of Medicine, Johns Hopkins University, Baltimore, MD (N.M., E.S.).
Josef CoreshDepartment of Epidemiology, Johns Hopkins University, Baltimore, MD (M.L., E.S., J.C.).
Suma KonetyDivision of General Internal Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN (S.K.).
Kenneth R ButlerDivision of Geriatrics, Department of Medicine, University of Mississippi, Jackson, MS (K.R.B., T.M.).
Thomas MosleyDivision of Geriatrics, Department of Medicine, University of Mississippi, Jackson, MS (K.R.B., T.M.).
Eric BoerwinkleDivision of Epidemiology and Public Health, University of Texas-Houston, Houston, TX (E.B.).
Ron HoogeveenSection of Cardiovascular Research, Department of Medicine, Baylor College of Medicine and Houston Methodist Debakey Heart and Vascular Center, Houston, TX (R.H., C.M.B.).
Christie M BallantyneSection of Cardiovascular Research, Department of Medicine, Baylor College of Medicine and Houston Methodist Debakey Heart and Vascular Center, Houston, TX (R.H., C.M.B.).
Scott D SolomonBrigham and Women's Hospital, Harvard Medical School, Boston, MA (B.C., S.C., S.D.S.).
Johns Hopkins University · USBrigham and Women's Hospital · USUniversity of Mississippi · USVanderbilt University Medical Center · USBaylor College of Medicine · USHarvard University · USHouston Methodist · USThe University of Texas Health Science Center at Houston · USUniversity of Minnesota · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Noninvasive Cardiovascular Imaging Research Training ProgramT32HL094301 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Marcelo F DI CARLI · 2010 to 2026
$7.8M
The Vanderbilt Emergency Medicine Research Training Program (VEMRT)K12HL109019 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COLLINS, SEAN PATRICK, STORROW, ALAN B · 2011 to 2015
$3.7M
Myocardial and Arterial Aging: Spectrum, Correlates, and PrognosisR00HL107642 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHENG, SUSAN · 2014 to 2016
$747k
NCATS NIH HHS UL1TR000445NHLBI NIH HHS K12 HL109019NHLBI NIH HHS K12HL109019NHLBI NIH HHS R00 HL107642NHLBI NIH HHS T32 HL094301PHS HHS HHSN268201100005CPHS HHS HHSN268201100006CPHS HHS HHSN268201100007CPHS HHS HHSN268201100008CPHS HHS HHSN268201100009CPHS HHS HHSN268201100010CPHS HHS HHSN268201100011CPHS HHS HHSN268201100012C
6 · The paper itself

Abstract

backgroundNatriuretic peptides promote natriuresis, diuresis, and vasodilation. Experimental deficiency of natriuretic peptides leads to hypertension (HTN) and cardiac hypertrophy, conditions more common among African Americans. Hospital-based studies suggest that African Americans may have reduced circulating natriuretic peptides, as compared to Caucasians, but definitive data from community-based cohorts are lacking. METHODS AND

resultsWe examined plasma N-terminal pro B-type natriuretic peptide (NTproBNP) levels according to race in 9137 Atherosclerosis Risk in Communities (ARIC) Study participants (22% African American) without prevalent cardiovascular disease at visit 4 (1996-1998). Multivariable linear and logistic regression analyses were performed adjusting for clinical covariates. Among African Americans, percent European ancestry was determined from genetic ancestry informative markers and then examined in relation to NTproBNP levels in multivariable linear regression analysis. NTproBNP levels were significantly lower in African Americans (median, 43 pg/mL; interquartile range [IQR], 18, 88) than Caucasians (median, 68 pg/mL; IQR, 36, 124; P<0.0001). In multivariable models, adjusted log NTproBNP levels were 40% lower (95% confidence interval [CI], -43, -36) in African Americans, compared to Caucasians, which was consistent across subgroups of age, gender, HTN, diabetes, insulin resistance, and obesity. African-American race was also significantly associated with having nondetectable NTproBNP (adjusted OR, 5.74; 95% CI, 4.22, 7.80). In multivariable analyses in African Americans, a 10% increase in genetic European ancestry was associated with a 7% (95% CI, 1, 13) increase in adjusted log NTproBNP.

conclusionsAfrican Americans have lower levels of plasma NTproBNP than Caucasians, which may be partially owing to genetic variation. Low natriuretic peptide levels in African Americans may contribute to the greater risk for HTN and its sequalae in this population.

Indexed as

AtherosclerosisBlack or African AmericanFemaleHumansHypertensionMaleMiddle AgedNatriuretic Peptide, BrainPeptide FragmentsResidence CharacteristicsRisk FactorsWhite PeopleNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)ancestry informative markersdeficiencyhypertensionnatriuretic peptiderace

Identifiers

PMID25999400
PMCPMC4599412
OpenAlexW2135769284

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.