ArticleAsian journal of andrology
Spermatozoa protein alterations in infertile men with bilateral varicocele.
Article in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Brief biology and pathophysiology of Tekt bundles.Cell adhesion & migration · 2025Review
- Genomic Insights into Fertilization: Tracing PLCZ1 Orthologs Across Amphibian Lineages.Genome biology and evolution · 2025Article
- Proteostasis as a Sentry for Sperm Quality and Male Fertility.Advances in experimental medicine and biology · 2025Review
- Proteomics and Metabolomics in Varicocele-Associated Male Infertility: Advancing Precision Diagnostics and Therapy.Journal of clinical medicine · 2024Review
- Review
- Increased TCP11 gene expression can inhibit the proliferation, migration and promote apoptosis of cervical cancer cells.BMC cancer · 2023Article
- Article
- Varicocele Embolization: Interventional Radiologist's Perspective.Seminars in interventional radiology · 2022Review
- Semen Proteomics of COVID-19 Convalescent Men Reveals Disruption of Key Biological Pathways Relevant to Male Reproductive Function.ACS omega · 2022Article
- Role of Oxidative Stress in Varicocele.Frontiers in genetics · 2022Review
- Molecular Interactions Associated with Oxidative Stress-Mediated Male Infertility: Sperm and Seminal Plasma Proteomics.Advances in experimental medicine and biology · 2022Review
- Article
- Alterations of Spermatozoa Proteomic Profile in Men with Hodgkin's Disease Prior to Cancer Therapy.The world journal of men's health · 2020Article
- Sperm and Seminal Plasma Proteomics: Molecular Changes Associated with Varicocele-Mediated Male Infertility.The world journal of men's health · 2020Review
- Alterations in seminal plasma proteomic profile in men with primary and secondary infertility.Scientific reports · 2020Article
- Proteomic Analyses of Human Sperm Cells: Understanding the Role of Proteins and Molecular Pathways Affecting Male Reproductive Health.International journal of molecular sciences · 2020Review
- Recent advances and controversies in diagnosing and treating male infertility.Faculty reviews · 2020Review
- The flagellar protein Enkurin is required for mouse sperm motility and for transport through the female reproductive tract.Biology of reproduction · 2018Article
- Update on the proteomics of male infertility: A systematic review.Arab journal of urology · 2018Article
- Genetic polymorphisms and haplotypes of the DJ-1 gene promoter associated with the susceptibility to male infertility.Journal of assisted reproduction and genetics · 2017Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Among infertile men, a diagnosis of unilateral varicocele is made in 90% of varicocele cases and bilateral in the remaining varicocele cases. However, there are reports of under-diagnosis of bilateral varicocele among infertile men and that its prevalence is greater than 10%. In this prospective study, we aimed to examine the differentially expressed proteins (DEP) extracted from spermatozoa cells of patients with bilateral varicocele and fertile donors. Subjects consisted of 17 men diagnosed with bilateral varicocele and 10 proven fertile men as healthy controls. Using the LTQ-orbitrap elite hybrid mass spectrometry system, proteomic analysis was done on pooled samples from 3 patients with bilateral varicocele and 5 fertile men. From these samples, 73 DEP were identified of which 58 proteins were differentially expressed, with 7 proteins unique to the bilateral varicocele group and 8 proteins to the fertile control group. Majority of the DEPs were observed to be associated with metabolic processes, stress responses, oxidoreductase activity, enzyme regulation, and immune system processes. Seven DEP were involved in sperm function such as capacitation, motility, and sperm-zona binding. Proteins TEKT3 and TCP11 were validated by Western blot analysis and may serve as potential biomarkers for bilateral varicocele. In this study, we have demonstrated for the first time the presence of DEP and identified proteins with distinct reproductive functions which are altered in infertile men with bilateral varicocele. Functional proteomic profiling provides insight into the mechanistic implications of bilateral varicocele-associated male infertility.
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