ArticleFish physiology and biochemistry2015
Effects of glutamate on growth, antioxidant capacity, and antioxidant-related signaling molecule expression in primary cultures of fish enterocytes.
Article in Fish physiology and biochemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
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- Effect of dietary isoleucine on skin mucus barrier and epithelial physical barrier functions of hybrid bagrid catfish Pelteobagrus vachelli × Leiocassis longirostris.Fish physiology and biochemistry · 2020Article
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- Attenuated glutamate induced ROS production by antioxidative compounds in neural cell lines.RSC advances · 2019Article
- Dietary tryptophan affects growth performance, digestive and absorptive enzyme activities, intestinal antioxidant capacity, and appetite and GH-IGF axis-related gene expression of hybrid catfish (Pelteobagrus vachelli♀ × Leiocassis longirostris♂).Fish physiology and biochemistry · 2019Article
- Arginine affects growth and integrity of grass carp enterocytes by regulating TOR signaling pathway and tight junction proteins.Fish physiology and biochemistry · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study explored the effects of glutamate (Glu) on the growth, antioxidant capacity, and gene expression of NF-E2-related nuclear factor 2 (Nrf2) signaling molecule in enterocytes of Jian carp (Cyprinus carpio var. Jian). The enterocytes were incubated in media containing 0, 2, 4, 6, 8, and 10 mM/L Glu for 96 h. The results showed that Glu could promote fish enterocytes proliferation and differentiation. Additionally, activities of alkaline phosphatase, Na(+), K(+)-ATPase, γ-glutamyl transpeptidase, and creatine kinase were significantly improved with the increase in Glu level up to 6 mM/L. Lactic acid dehydrogenase activity and malondialdehyde content in the medium and cellular protein carbonyls were depressed by Glu. Moreover, optimum Glu significantly enhanced glutathione content and the activities and gene expression of catalase, glutathione reductase, and glutathione peroxidase in enterocytes. Finally, the expression level of Nrf2 in enterocytes was significantly elevated by appropriate Glu content in the medium. Furthermore, optimum Glu significantly decreased Kelch-like ECH-associated protein 1 mRNA level in enterocytes. In conclusion, Glu improved the proliferation, function, and antioxidant capacity and regulated antioxidant-related signaling molecule expression of fish enterocytes.
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