Trial reportDiagnostic microbiology and infectious disease2015
Comparison of asymptomatic and symptomatic rhinovirus infections in university students: incidence, species diversity, and viral load.
Trial report in Diagnostic microbiology and infectious disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Asymptomatic Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: Extent and implications for infection control: A systematic review.Travel medicine and infectious diseasePooled it
- ColdZyme® reduces viral load and upper respiratory tract infection duration and protects airway epithelia from infection with human rhinoviruses.The Journal of physiology · 2025Trial
- Viral load is strongly associated with length of stay in adults hospitalised with viral acute respiratory illness.The Journal of infection · 2016Trial
- Age-Related Asymptomatic Rhinovirus Infections Contribute to the Sustained Prevalence in Adults and Are Not Mitigated by Nonpharmaceutical Interventions.Influenza and other respiratory viruses · 2026Article
- Molecular detection of respiratory pathogens in tonsillar tissue from asymptomatic children: implications for result interpretation among the asymptomatic and symptomatic.Microbiology spectrum · 2026Article
- Hidden in plain sight: the impact of human rhinovirus infection in adults.Respiratory research · 2025Review
- Will COVID-19 become mild, like a cold?Epidemiology and infection · 2024Review
- An outbreak of rhinovirus infection in a primary school in Shenyang City, China, in 2022.Biosafety and health · 2024Article
- Common cold viruses circulating in children threaten wild chimpanzees through asymptomatic adult carriers.Scientific reports · 2024Article
- Rhinovirus induces airway remodeling: what are the physiological consequences?Respiratory research · 2023Review
- Temperature dependent viral tropism: understanding viral seasonality and pathogenicity as applied to the avoidance and treatment of endemic viral respiratory illnesses.Reviews in medical virology · 2022Review
- Detection of SARS-CoV-2 infection in asymptomatic populations using the DiaSorin molecular Simplexa and Roche Cobas EUA assays.Diagnostic microbiology and infectious disease · 2022Article
- Personal Network Inference Unveils Heterogeneous Immune Response Patterns to Viral Infection in Children with Acute Wheezing.Journal of personalized medicine · 2021Article
- Gold-Oligonucleotide Nanoconstructs Engineered to Detect Conserved Enteroviral Nucleic Acid Sequences.Biosensors · 2021Article
- Lessons from a local effort to screen for SARS-CoV-2.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Article
- Neutrophils and Lymphocytes Can Help Distinguish Asymptomatic COVID-19 From Moderate COVID-19.Frontiers in cellular and infection microbiology · 2021Article
- Article
- Repeat Molecular Testing for Respiratory Pathogens: Diagnostic Gain or Diminishing Returns?The journal of applied laboratory medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human rhinovirus (HRV) infections are common but poorly characterized in university students. Thus, we characterized asymptomatic and symptomatic HRV infections by incidence, species diversity, and viral load of 502 university students during September and October of 2010 and 2011 from nasal swabs and electronically submitted symptom questionnaires. We tested all symptomatic students and randomly sampled participants who remained asymptomatic (n=25/week, over 8 weeks each study year) on a weekly basis by real-time PCR and sequenced HRV positives. HRV was identified in 33/400 (8.3%) and 85/92 (92.4%) of the asymptomatic and symptomatic students, respectively. We identified a higher than previously reported rate of HRV-B in both groups, although the distribution of HRV species was similar (P=0.37). Asymptomatic viral load averaged 1.2 log10 copies/mL lower than symptomatic HRV (P<0.001). In conclusion, asymptomatic HRV activity preceded peak symptomatic activity in September and October and was associated with lower viral load.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.