Evidence map›Paper›PMID 25999228›Full record

ReviewInfectious disease clinics of North America2015

Human granulocytic anaplasmosis.

Johan S Bakken, J Stephen Dumler

Open access · greenAbstract readReview
In one paragraph

Review in Infectious disease clinics of North America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers.

0numbers the graph read from it
0cells of the map it votes in
175citing papers in PubMed
25.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

175 citing papers in PubMed, 408 citations in OpenAlex.

  1. Article
  2. Pathogens (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Machine Learning-Based Detection ofPathogens (Basel, Switzerland) · 2026
    Article
  5. Article
  6. Coinfection ecology and pathogen emergence in aApplied and environmental microbiology · 2026
    Article
  7. Article
  8. Article
  9. mBio · 2026
    Article
  10. Trends in Anaplasmosis Over the Past Decade: A Review of Clinical Features, Laboratory Data, and Outcomes.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Mitochondrial Dysfunction inTransboundary and emerging diseases · 2026
    Review
  19. Article
  20. Coinfection Ecology and Pathogen Emergence in amedRxiv : the preprint server for health sciences · 2025
    Article

115 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Johan S BakkenDepartment of Family Medicine, University of Minnesota School of Medicine, Duluth, MN, USA; St. Luke's Infectious Disease Associates, 1001 East Superior Street, Suite L201, Duluth, MN 55802, USA.
J Stephen DumlerDepartment of Pathology, University of Maryland School of Medicine, 685 West Baltimore Street, HSF1 322D, Baltimore, MD 21201, USA; Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: sdumler@som.umaryland.edu.
University of Maryland, Baltimore · USUniversity of Minnesota, Duluth · US

Funding

EHRLICHIA-GRANULOCYTE INTERACTIONS AND INFECTIONR01AI044102 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI DUMLER, JOHN STEPHEN · 2000 to 2019
$5.3M
NIAID NIH HHS R01 AI044102NIAID NIH HHS R01AI44102
6 · The paper itself

Abstract

Human granulocytic anaplasmosis, a deer tick-transmitted rickettsial infection caused by Anaplasma phagocytophilum, is a common cause of undifferentiated fever in the northeast and upper Midwest United States. Patients are often initially diagnosed with a mild viral infection, and illness readily resolves in most cases. However, as many as 3% develop life-threatening complications and nearly 1% die from the infection. Although coinfections with Borrelia burgdorferi and Babesia microti occur, there is little evidence to suggest synergism of disease or a role for A phagocytophilum in chronic illness. No vaccine is available.

Indexed as

AnaplasmosisAnaplasma phagocytophilumFeverGranulocytesHumansRisk FactorsAnaplasmosisDiagnosisGranulocyticHumanManagement

Identifiers

PMID25999228
PMCPMC4441757
OpenAlexW2075556106

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.