ReviewInfectious disease clinics of North America2015
Chronic Lyme disease.
Review in Infectious disease clinics of North America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Characteristics of Lyme optic neuritis: a case report of Lyme associated bilateral optic neuritis and systematic review of the literature.BMC neurology · 2022Pooled it
- A systematic review on the impact of gestational Lyme disease in humans on the fetus and newborn.PloS one · 2018Pooled it
- A second yearly booster dose of the VLA15 Lyme borreliosis vaccine candidate in healthy individuals.Nature communications · 2026Trial
- Symptom load and general function among patients with erythema migrans: a prospective study with a 1-year follow-up after antibiotic treatment in Norwegian general practice.Scandinavian journal of primary health care · 2017Trial
- Testing the capacity of humanized immune system mice to induce a protective antibody response against the Lyme disease pathogen.Microbiology spectrum · 2026Article
- Prevalence and clinical characteristics of Norwegians who report persistent health complaints attributed to tick bites or tick-borne diseases.BMC infectious diseases · 2025Article
- In Search of Molecular Correlates of Fibromyalgia: The Quest for Objective Diagnosis and Effective Treatments.International journal of molecular sciences · 2025Review
- Reassessing Chronic Lyme Disease and Post-Treatment Lyme Disease Syndrome as Focal Infections.Cureus · 2025Article
- Somatic symptom and related disorders: Guidance on assessment and management for paediatric health care providers.Paediatrics & child health · 2025Review
- Les troubles à symptomatologie somatique et apparentés: directives d'évaluation et de prise en charge pour les professionnels de la santé des enfants.Paediatrics & child health · 2025Review
- Persistent self-reported health complaints in Norwegians who attribute their symptoms to tick bites or tick-borne disease- a cross-sectional controlled study.BMC infectious diseases · 2025Article
- Bridging the gap: Insights in the immunopathology of Lyme borreliosis.European journal of immunology · 2024Review
- Case presentation and management of Lyme disease patients: a 9-year retrospective analysis in France.Frontiers in medicine · 2023Article
- "It's not all nice and fun": Narrating contested illness on YouTube and Instagram.Health (London, England : 1997) · 2022Article
- A taxonomy of risk-associated alternative health practices: A Delphi study.Health & social care in the community · 2022Article
- A Review of Post-treatment Lyme Disease Syndrome and Chronic Lyme Disease for the Practicing Immunologist.Clinical reviews in allergy & immunology · 2022Review
- Design theory to better target public health priorities: An application to Lyme disease in France.Frontiers in public health · 2022Article
- Chronic pain and infection: mechanisms, causes, conditions, treatments, and controversies.BMJ medicine · 2022Review
- Chronic Fatigue Syndrome: A Case Report Highlighting Diagnosing and Treatment Challenges and the Possibility of Jarisch-Herxheimer Reactions If High Infectious Loads Are Present.Healthcare (Basel, Switzerland) · 2021Article
- Seroprevalence of Antibodies against Tick-Borne Pathogens in Czech Patients with Suspected Post-Treatment Lyme Disease Syndrome.Microorganisms · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Chronic Lyme disease is a poorly defined diagnosis that is usually given to patients with prolonged, unexplained symptoms or with alternative medical diagnoses. Data do not support the proposition that chronic, treatment-refractory infection with Borrelia burgdorferi is responsible for the many conditions that get labeled as chronic Lyme disease. Prolonged symptoms after successful treatment of Lyme disease are uncommon, but in rare cases may be severe. Prolonged courses of antibiotics neither prevent nor ameliorate these symptoms and are associated with considerable harm.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.