Evidence map›Paper›PMID 25999185›Full record

ArticleOrganic & biomolecular chemistry2015

Genetic encoding of the post-translational modification 2-hydroxyisobutyryl-lysine.

William A Knight, T Ashton Cropp

Abstract read
In one paragraph

Article in Organic & biomolecular chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Playing with the Molecules of Life.ACS chemical biology · 2018
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

William A KnightDepartment of Chemistry, Virginia Commonwealth University, 1001 W. Main Street, Richmond, Virginia 23284, USA. tacropp@vcu.edu.
T Ashton Cropp

Funding

Scanning amino acid mutagenesis for protein engineeringR01GM084396 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI CROPP, THOMAS ASHTON · 2008 to 2015
$1.0M
NIGMS NIH HHS GM084396NIGMS NIH HHS R01 GM084396
6 · The paper itself

Abstract

We report the synthesis and genetic encoding of a recently discovered post-translational modification, 2-hydroxyisobutyryl-lysine, to the genetic code of E. coli. The production of homogeneous proteins containing this amino acid will facilitate the study of modification in full-length proteins.

Indexed as

Amino Acid SequenceAmino Acyl-tRNA SynthetasesEscherichia coliEscherichia coli ProteinsGreen Fluorescent ProteinsLysineLysine-tRNA LigaseMethanosarcinaMolecular Sequence DataProtein Processing, Post-TranslationalSubstrate Specificity2-hydroxyisobutyryl-lysineAmino Acyl-tRNA SynthetasesEscherichia coli ProteinsGreen Fluorescent ProteinsLysineLysine-tRNA Ligase

Identifiers

PMID25999185
PMCPMC4457286

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.