Evidence map›Paper›PMID 25998732›Full record

ReviewBiochemical and biophysical research communications2015

Store-operated calcium entry: Mechanisms and modulation.

Patrick G Hogan, Anjana Rao

Abstract readReview
In one paragraph

Review in Biochemical and biophysical research communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

131 citing papers in PubMed.

  1. Review
  2. Article
  3. Orai1-mediated CaExperimental & molecular medicine · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Shear stress-induced CaBiological research · 2026
    Article
  9. Article
  10. Review
  11. Review
  12. Functional analysis of CaParasitology · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Effects of aging on calcium channels in skeletal muscle.Frontiers in molecular biosciences · 2025
    Review
  19. Calcium Ions in the Physiology and Pathology of the Central Nervous System.International journal of molecular sciences · 2024
    Review
  20. Review

71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Patrick G HoganLa Jolla Institute for Allergy & Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA. Electronic address: phogan@liai.org.
Anjana RaoLa Jolla Institute for Allergy & Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA. Electronic address: arao@liai.org.

Funding

SIGNAL TRANSDUCTION AND GENE INDUCTION IN T LYMPHOCYTESR01AI040127 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI HOGAN, PATRICK, RAO, ANJANA · 1996 to 2025
$13.3M
STIM-ORAI signaling and other calcium influx pathways in lymphocytesR01AI084167 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI HOGAN, PATRICK · 2009 to 2019
$4.9M
Nanoscale regulation of store-operated calcium entry through STIM-ORAI signallingR01GM110397 · NIGMS · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI HOGAN, PATRICK, LILLEMEIER, BJOERN F · 2014 to 2017
$1.4M
NIAID NIH HHS AI 040127NIAID NIH HHS AI 084167NIAID NIH HHS R01 AI040127NIAID NIH HHS R01 AI084167NIGMS NIH HHS GM 110397NIGMS NIH HHS R01 GM110397
6 · The paper itself

Abstract

Store-operated calcium entry is a central mechanism in cellular calcium signalling and in maintaining cellular calcium balance. This review traces the history of research on store-operated calcium entry, the discovery of STIM and ORAI as central players in calcium entry, and the role of STIM and ORAI in biology and human disease. It describes current knowledge of the basic mechanism of STIM-ORAI signalling and of the varied mechanisms by which STIM-ORAI signalling can be modulated.

Indexed as

Models, BiologicalAnimalsCalciumCalcium ChannelsCalcium SignalingCell MembraneHumansIon Channel GatingMembrane ProteinsORAI1 ProteinCalciumCalcium ChannelsMembrane ProteinsORAI1 ProteinORAI1 protein, humanCalcium channelCRAC currentORAI1STIM1Store-operated calcium entry

Identifiers

PMID25998732
PMCPMC4441756

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.