Evidence map›Paper›PMID 25998147›Full record

ArticleBMC health services research2015

Antidementia drug treatment in dementia networks in Germany: use rates and factors associated with treatment use.

Markus Wübbeler, Diana Wucherer, Johannes Hertel, Bernhard Michalowsky, Steffen Heinrich, Saskia Meyer, Susanne Schaefer-Walkmann, Wolfgang Hoffmann, Jochen René Thyrian

Open access · goldAbstract read
In one paragraph

Article in BMC health services research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Treatment Patterns of Patients with All-Cause Dementia in Russia.Journal of Alzheimer's disease reports · 2020
    Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Markus WübbelerGerman Center for Neurodegenerative Diseases (DZNE), Research Group "Interventional Health Care Research", Site Rostock/Greifswald, Ellernholzstr. 1-2, Greifswald, D-17487, Germany. markus.wuebbeler@dzne.de.
Diana WuchererGerman Center for Neurodegenerative Diseases (DZNE), Site Rostock/ Greifswald, Ellernholzstr. 1-2, Greifswald, D-17487, Germany. diana.wucherer@dzne.de.
Johannes HertelGerman Center for Neurodegenerative Diseases (DZNE), Site Rostock/ Greifswald, Ellernholzstr. 1-2, Greifswald, D-17487, Germany. Johannes.Hertel@dzne.de.
Bernhard MichalowskyGerman Center for Neurodegenerative Diseases (DZNE), Site Rostock/ Greifswald, Ellernholzstr. 1-2, Greifswald, D-17487, Germany. Bernhard.Michalowsky@dzne.de.
Steffen HeinrichGerman Center for Neurodegenerative Diseases (DZNE), Research Group "Care Structures" Site Witten, Stockumer Str. 12, Witten, D-58453, Germany. steffen.heinrich@dzne.de.
Saskia MeyerDepartment of Human and Health Science, University of Bremen, Grazer Str. 4, Bremen, D-28359, Germany. saskia.meyer@uni-bremen.de.
Susanne Schaefer-WalkmannInstitute for Applied Social Sciences, Rotebühlstr. 131, Stuttgart, D-70197, Germany. s.schaefer-walkmann@ifas-stuttgart.de.
Wolfgang HoffmannGerman Center for Neurodegenerative Diseases (DZNE), Site Rostock/ Greifswald, Ellernholzstr. 1-2, Greifswald, D-17487, Germany. wolfgang.hoffmann@uni-greifswald.de.
Jochen René ThyrianGerman Center for Neurodegenerative Diseases (DZNE), Research Group "Interventional Health Care Research", Site Rostock/Greifswald, Ellernholzstr. 1-2, Greifswald, D-17487, Germany. rene.thyrian@dzne.de.
German Center for Neurodegenerative Diseases · DEUniversitätsmedizin Greifswald · DEUniversity of Bremen · DEUniversity of Stuttgart · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDementia networks in Germany constitute a specialised setting for integrated dementia care and have shown benefits on relevant outcomes, including those of drug treatment. National guidelines recommend treatment with acetylcholinesterase inhibitors (donepezil, galantamine, rivastigmine) or the N-Methyl-D-Aspartate antagonist (memantine) to reduce cognitive symptoms. However, prescription rates are lower than 30 % in general practises. This study aims to describe antidementia drug treatment and the factors that are associated with the treatment in different dementia networks across Germany.

methodsWe have analysed the socio-demographic, clinical and utilisation data from 560 patients with dementia (PWD), as well as data from their caregivers, in 13 selected dementia networks in Germany. The patients and caregivers were interviewed in their homes or in the network facilities. Multiple logistic regression models were fitted to evaluate the socio-demographic and clinical factors associated with the utilisation of antidementia drug treatment in the various networks.

resultsIn all of the networks in the study, 52 % of the participants received an antidementia drug treatment. Factors associated with the utilisation of the antidementia drug treatment were: formal diagnosis (OR = 16.81, p < 0.001), association with a physician in the network (OR = 3.69, p < 0.001), higher number of comorbidities (OR = 0.88, p = 0.039), living alone (OR = 0.51, p = 0.032) and higher age (OR = 2.97, p = 0.002).

conclusionMedical treatment of PWD with antidementia drugs in dementia networks in Germany is more frequent than in primary and nursing home care settings. Our findings also suggest that participants with a formal diagnosis and a physician in the network have increased rates of receiving antidementia drug treatments. These findings suggest that dementia networks focusing on medical treatment should support diagnostic procedures and incorporate physician specialists.

Indexed as

AgedAged, 80 and overCaregiversCholinesterase InhibitorsDementiaDonepezilDopamine AgentsFemaleGalantamineGermanyHumansIndansInterviews as TopicLogistic ModelsMaleMemantineCholinesterase InhibitorsDonepezilDopamine AgentsGalantamineIndansMemantineNeuroprotective AgentsNootropic AgentsPiperidinesRivastigmine

Identifiers

PMID25998147
PMCPMC4460966
OpenAlexW1557116191

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.