ArticleObesity surgery2016
Comparing the Effectiveness of Total Gastrectomy and Gastric Bypass on Glucose Metabolism in Diabetic Rats.
Article in Obesity surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Long-Term Diabetes Improvement After Duodenal Exclusion in Zucker Diabetic Fatty Rats Is Associated with Prevention of Strain-Specific Pancreatic Remodeling and Increased Beta Cell Proliferation.Obesity surgery · 2022Article
- Article
- Alterations in Small Intestine and Liver Morphology, Immunolocalization of Leptin, Ghrelin and Nesfatin-1 as Well as Immunoexpression of Tight Junction Proteins in Intestinal Mucosa after Gastrectomy in Rat Model.Journal of clinical medicine · 2021Article
- Roux-en-Y Gastric Bypass Improves Metabolic Conditions in Association with Increased Serum Bile Acids Level and Hepatic Farnesoid X Receptor Expression in a T2DM Rat Model.Obesity surgery · 2019Article
- Ghrelin regulates sepsis‑induced rat acute gastric injury.Molecular medicine reports · 2019Article
- The Effect of Gastric Bypass with a Distal Gastric Pouch on Glucose Tolerance and Diabetes Remission in Type 2 Diabetes Sprague-Dawley Rat Model.Obesity surgery · 2019Article
- Sudden development of adult-onset type II citrullinemia after total gastrectomy: a case report.Surgical case reports · 2018Article
- Increased β-Cell Mass in Obese Rats after Gastric Bypass: A Potential Mechanism for Improving Glycemic Control.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBariatric surgeries have been widely used in obesity associated type II diabetes. However, the mechanisms of surgical treatments for type II diabetes in non-obese patients remain controversial. Our study aims to compare the effectiveness of various bariatric surgeries in a non-obese diabetic rat model.
methodsGoto-Kakisaki (GK) rats were used to compare the outcome of total gastrectomy (TG), Roux-en-Y reconstruction after total gastrectomy (RYTG), and Roux-En-Y gastric bypass (RYGB). Body weight, food and water intake, and glucose level were monitored prior to and after surgery. Oral glucose tolerance tests (OGTT) were performed, and key metabolic hormones were measured at selected time points.
resultsDespite a significant reduction in body weight in TG and RYTG groups, their glucose metabolic rate was not improved. RYGB rats, with only moderate reduction in food intake and body weight, had significantly improved glucose metabolism. Insulin and ghrelin were significantly reduced in TG and RYTG groups, but remained unchanged in RYGB group.
conclusionsOur study demonstrated the effectiveness of RYGB surgery in treating type II diabetes in non-obese diabetic rats. These results suggest an important role of gastric system in regulating glucose homeostasis.
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