Evidence map›Paper›PMID 25998118›Full record

ReviewThe Psychiatric clinics of North America2015

The use of cerebrospinal fluid and neuropathologic studies in neuropsychiatry practice and research.

Kalyani Kansal, David J Irwin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Psychiatric clinics of North America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kalyani KansalDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 550 North Broadway, Suite 305, Baltimore, MD 21205, USA.
David J IrwinDepartment of Neurology, Hospital of the University of Pennsylvania, University of Pennsylvania Perelman School of Medicine, 3 Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA. Electronic address: dirwin@mail.med.upenn.edu.

Funding

Identification of Endophenotypes in the Behavioral-Variant of Frontotemporal DemeK23NS088341 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI IRWIN, DAVID JOHN · 2014 to 2018
$836k
NINDS NIH HHS K23 NS088341NINDS NIH HHS K23NS088341-01
6 · The paper itself

Abstract

The gold standard for diagnosis of neurodegenerative diseases (ie, Alzheimer disease, frontotemporal dementia, Parkinson disease, dementia with Lewy bodies, amyotrophic lateral sclerosis) is neuropathologic examination at autopsy. As such, laboratory studies play a central role in antemortem diagnosis of these conditions and their differentiation from the neuroinflammatory, infectious, toxic, and other nondegenerative etiologies (eg, rapidly progressive dementias) that are encountered in neuropsychiatric practice. This article summarizes the use of cerebrospinal fluid (CSF) laboratory studies in the diagnostic evaluation of dementia syndromes and emerging CSF biomarkers specific for underlying neuropathology in neurodegenerative disease research.

Indexed as

Cerebrospinal FluidDementiaNeurodegenerative Diseasesalpha-SynucleinAmyloid beta-PeptidesBiomarkersBrainDisease ProgressionDNA-Binding ProteinsHumansNeuropsychiatryalpha-SynucleinAmyloid beta-PeptidesBiomarkersDNA-Binding ProteinsAlzheimer diseaseBiomarkersCSFDementia with Lewy bodiesFrontotemporal dementiaNeurodegenerative diseaseParkinson diseasePrion

Identifiers

PMID25998118
PMCPMC4443852

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.