ReviewMedical science monitor : international medical journal of experimental and clinical research2015
Hypoxia defined as a common culprit/initiation factor in mitochondrial-mediated proinflammatory processes.
Review in Medical science monitor : international medical journal of experimental and clinical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- The Anatomical and Evolutionary Impact of Pain, Pleasure, Motivation, and Cognition: Integrating Energy Metabolism and the Mind-Body BERN (Behavior, Exercise, Relaxation, and Nutrition) Framework.International journal of molecular sciences · 2025Review
- Independent and sensory human mitochondrial functions reflecting symbiotic evolution.Frontiers in cellular and infection microbiology · 2023Review
- Dysfunctional mitochondrial processes contribute to energy perturbations in the brain and neuropsychiatric symptoms.Frontiers in pharmacology · 2022Review
- Behaviorally-Mediated Entrainment of Whole-Body Metabolic Processes: Conservation and Evolutionary Development of Mitochondrial Respiratory Complexes.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Augmentation of Whole-Body Metabolic Status by Mind-Body Training: Synchronous Integration of Tissue- and Organ-Specific Mitochondrial Function.Medical science monitor basic research · 2019Review
- Microbiome and Health: Ramifications of Intelligent Deception.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Microbiome: A Potential Component in the Origin of Mental Disorders.Medical science monitor : international medical journal of experimental and clinical research · 2017Review
- Aging Reversal and Healthy Longevity is in Reach: Dependence on Mitochondrial DNA Heteroplasmy as a Key Molecular Target.Medical science monitor : international medical journal of experimental and clinical research · 2017Review
- Animal models to improve our understanding and treatment of suicidal behavior.Translational psychiatry · 2017Review
- Hyperglycemia-associated alterations in cellular signaling and dysregulated mitochondrial bioenergetics in human metabolic disorders.European journal of nutrition · 2016Review
- Glycolytic Coupling to Mitochondrial Energy Production Ensures Survival in an Oxygen Rich Environment.Medical science monitor : international medical journal of experimental and clinical research · 2016Review
- Mitochondrial DNA heteroplasmy in human health and disease.Biomedical reports · 2016Article
- Dysregulated mitochondrial and chloroplast bioenergetics from a translational medical perspective (Review).International journal of molecular medicine · 2016Review
- Cancer: Mitochondrial Origins.Medical science monitor : international medical journal of experimental and clinical research · 2015Review
- Mitochondria, Chloroplasts in Animal and Plant Cells: Significance of Conformational Matching.Medical science monitor : international medical journal of experimental and clinical research · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mammals and invertebrates, the activities of neuro- and immuno-competent cells, e.g., glia, which are present in nervous tissues, are deemed of critical importance to normative neuronal function. The responsiveness of invertebrate and vertebrate immuno-competent glia to a common set of signal molecules, such as nitric oxide and endogenous morphine, is functionally linked to physiologically driven innate immunological and neuronal activities. Importantly, the presence of a common, evolutionarily conserved, set of signal molecules in comparative animal groups strongly suggests an expansive intermediate metabolic profile dependent on high output mitochondrial ATP production and utilization. Normative bidirectional neural-immune communication across invertebrate and vertebrate species requires common anatomical and biochemical substrates and pathways involved in energy production and mitochondrial integrity. Within this closed-loop system, abnormal perturbation of the respective tissue functions will have profound ramifications in functionally altering associated nervous and vascular systems and it is highly likely that the initial trigger to the induction of a physiologically debilitating pro-inflammatory state is a micro-environmental hypoxic event. This is surmised by the need for an unwavering constant oxygen supply. In this case, temporal perturbations of normative oxygen tension may be tolerated for short, but not extended, periods and ischemic/hypoxic perturbations in oxygen delivery represent significant physiological challenges to overall cellular and multiple organ system viability. Hence, hypoxic triggering of multiple pro-inflammatory events, if not corrected, will promote pathophysiological amplification leading to a deleterious cascade of bio-senescent cellular and molecular signaling pathways, which converge to markedly impair mitochondrial energy utilization and ATP production.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.