ArticleDevelopment and psychopathology2015
Methylation of exons 1D, 1F, and 1H of the glucocorticoid receptor gene promoter and exposure to adversity in preschool-aged children.
Article in Development and psychopathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- A systematic review of childhood maltreatment and DNA methylation: candidate gene and epigenome-wide approaches.Translational psychiatry · 2021Pooled it
- Adverse Childhood Events and Health Biomarkers: A Systematic Review.Frontiers in public health · 2021Pooled it
- Aberrant Epigenomic Modulation of Glucocorticoid Receptor Gene (NR3C1) in Early Life Stress and Major Depressive Disorder Correlation: Systematic Review and Quantitative Evidence Synthesis.International journal of environmental research and public health · 2019Pooled it
- Long-Term Alterations of Glucocorticoid Receptor Expression and CD4Biomolecules · 2025Article
- Methylation of the Glucocorticoid Receptor Gene in Children with Somatic Symptom Disorder: A Case-Control Study.Epigenomes · 2025Article
- Examining the Biological Impacts of Parent-Child Relationship Dynamics on Preschool-Aged Children who have Experienced Adversity.Developmental psychobiology · 2024Observational
- Developmental Dyslexia: Insights from EEG-Based Findings and Molecular Signatures-A Pilot Study.Brain sciences · 2024Article
- The Mood, Mother and Child Study: Protocol for a Prospective Longitudinal Study and Randomized Controlled Trial.JMIR research protocols · 2023Article
- Article
- How can early life adversity still exert an effect decades later? A question of timing, tissues and mechanisms.Frontiers in immunology · 2023Review
- Role of microRNAs and long non‑coding RNAs in glucocorticoid signaling (Review).International journal of molecular medicine · 2022Review
- Antenatal Steroids and Cord Blood T-cell Glucocorticoid Receptor DNA Methylation and Exon 1 Splicing.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- The Traumatizing Impact of Racism in Canadians of Colour.Current trauma reports · 2022Review
- Glucocorticoid Signaling and Epigenetic Alterations in Stress-Related Disorders.International journal of molecular sciences · 2021Review
- Effect of Early Life Stress on the Epigenetic Profiles in Depression.Frontiers in cell and developmental biology · 2020Review
- Implication of Spiritual Network Support System in Epigenomic Modulation and Health Trajectory.International journal of environmental research and public health · 2019Review
- Childhood maltreatment, behavioral adjustment, and molecular markers of cellular aging in preschool-aged children: A cohort study.Psychoneuroendocrinology · 2019Article
- Looking back and moving forward: Evaluating and advancing translation from animal models to human studies of early life stress and DNA methylation.Developmental psychobiology · 2019Article
- Glucocorticoid receptor alpha translational isoforms as mediators of early adversities and negative emotional states.Progress in neuro-psychopharmacology & biological psychiatry · 2019Article
- NeonatalFrontiers in behavioral neuroscience · 2019Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Epigenetic modifications to the genome are a key mechanism involved in the biological encoding of experience. Animal studies and a growing body of literature in humans have shown that early adversity is linked to methylation of the gene for the glucocorticoid receptor (GR), which is a key regulator of the hypothalamic-pituitary-adrenal axis as well as a broad range of physiological systems including metabolic and immune function. One hundred eighty-four families participated, including n = 74 with child welfare documentation of moderate-severe maltreatment in the past 6 months. Children ranged in age from 3 to 5 years, and were racially and ethnically diverse. Structured record review and interviews in the home were used to assess a history of maltreatment, other traumas, and contextual life stressors, and a composite variable assessed the number exposures to these adversities. Methylation of regions 1(D), 1(F), and 1(H) of the GR gene was measured via sodium bisulfite pyrosequencing. The composite measure of adversity was positively correlated with methylation at exons 1(D) and 1(F) in the promoter of the GR gene. Individual stress measures were significantly associated with a several CpG sites in these regions. GR gene methylation may be a mechanism of the biobehavioral effects of adverse exposures in young children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.