ArticleDevelopment and psychopathology2015
Adversity in preschool-aged children: Effects on salivary interleukin-1β.
Article in Development and psychopathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Early life adversity exposure and circulating markers of inflammation in children and adolescents: A systematic review and meta-analysis.Brain, behavior, and immunity · 2020Pooled it
- Inflammatory Stress Response During Pregnancy as a Connecting Link in Intergenerational Risk Cascades.Developmental psychobiology · 2026Article
- Discrimination Against Immigrant Latina Mothers Associated With Pro-Inflammatory Gene Expression in Their Preschool-Aged Children.Biological research for nursing · 2026Article
- The role of social support on change in C-reactive Protein and BMI among youth with and without child maltreatment history.Brain, behavior, and immunity · 2026Article
- Disproportionality Analysis of Adverse Events Associated with IL-1 Inhibitors in the FDA Adverse Event Reporting System (FAERS).Pharmaceuticals (Basel, Switzerland) · 2025Article
- A Brief Historic Review of Research on Early Life Stress and Inflammation across the Lifespan.Neuroimmunomodulation · 2025Review
- Analysis of the impact of clinical practices on salivary biomarkers of inflammation and stress in oral surgery postgraduate students: a pilot study.Frontiers in medicine · 2025Article
- Inflammatory burden of adolescents with childhood maltreatment: results from baseline data of a school cohort.European child & adolescent psychiatry · 2024Article
- Linking specific biological signatures to different childhood adversities: findings from the HERO project.Pediatric research · 2023Article
- Early Life Stress, Neuroinflammation, and Psychiatric Illness of Adulthood.Advances in experimental medicine and biology · 2023Review
- Gender- and age-specific associations of childhood maltreatment with peripheral serum inflammatory cytokines in middle school students.Frontiers in immunology · 2023Article
- Perinatal and early childhood biomarkers of psychosocial stress and adverse experiences.Pediatric research · 2022Review
- The intergenerational interplay of adversity on salivary inflammation in young children and caregivers.Psychoneuroendocrinology · 2021Article
- Maltreatment exposure across childhood and low-grade inflammation: Considerations of exposure type, timing, and sex differences.Developmental psychobiology · 2021Article
- Effects of Early-Life Stress, Postnatal Diet Modulation and Long-Term Western-Style Diet on Peripheral and Central Inflammatory Markers.Nutrients · 2021Article
- Interpersonal life stress, inflammation, and depression in adolescence: Testing Social Signal Transduction Theory of Depression.Depression and anxiety · 2020Article
- Adverse childhood experiences and biomarkers of inflammation in a diverse cohort of early school-aged children.Brain, behavior, & immunity - health · 2020Article
- Determining the biological associates of acute cold pressor post-encoding stress effects on human memory: The role of salivary interleukin-1β.Brain, behavior, and immunity · 2019Article
- Pathways between early-life adversity and adolescent self-harm: the mediating role of inflammation in the Avon Longitudinal Study of Parents and Children.Journal of child psychology and psychiatry, and allied disciplines · 2019Article
- Chronic Stress in Children and Adolescents: A Review of Biomarkers for Use in Pediatric Research.Biological research for nursing · 2018Article
Corrections and comments
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5 authors.
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Abstract
Exposure to early life adversity is linked to impaired affective, cognitive, and behavioral functioning and increases risk for various psychiatric and medical conditions. Stress-induced increases in pro-inflammatory cytokines may be a biological mechanism of these effects. Few studies have examined cytokine levels in children experiencing early life adversity, and very little research has investigated cytokines or other markers of inflammation in saliva. In the present study, we examined salivary interleukin (IL)-1β and C-reactive protein (CRP) levels in relation to stress exposure in 40 children aged 3 to 5 years who were enrolled in a larger study of early life adversity. Childhood maltreatment status was assessed via review of child welfare records. Contextual stress exposure, traumatic life event history, and symptoms of psychopathology were assessed via caregiver interviews at a home visit. In a subsequent visit, salivary IL-1β and CRP were obtained before and after participation in four emotion-eliciting tasks. The number of past-month contextual stressors, lifetime contextual stressors, and traumatic life events each demonstrated a significant main effect on IL-1β. Baseline IL-1β was positively associated with each of the significant main-effect adversities. Postchallenge IL-1β displayed positive associations with each adversity variable, but these were not significant. CRP was not significantly associated with any of the adversity variables. Given the evidence suggesting the involvement of IL-1β in the neuropathology of psychiatric conditions, these results may have important implications for developmental outcomes.
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