ReviewDevelopment and psychopathology2015
Using cross-species comparisons and a neurobiological framework to understand early social deprivation effects on behavioral development.
Review in Development and psychopathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Sensitive periods in development and risk for psychiatric disorders and related endpoints: a systematic review of child maltreatment findings.The lancet. Psychiatry · 2022Pooled it
- Associations between Early Psychosocial Deprivation, Cognitive and Psychiatric Morbidity, and Risk-taking Behavior in Adolescence.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Trial
- MRI-based structural development of the human newborn hypothalamus.Developmental cognitive neuroscience · 2026Article
- The Social Relevance of Numbers: Insights from Animal Studies.Life (Basel, Switzerland) · 2025Review
- Childhood adversity and adolescent mental health: Examining cumulative and specificity effects across contexts and developmental timing.Development and psychopathology · 2025Article
- Longitudinal investigation of neurobiological changes across pregnancy.Communications biology · 2025Article
- The Impact of Early Life Experiences on Stress Neurobiology and the Development of Anxiety.Current topics in behavioral neurosciences · 2025Review
- Within arms reach: Physical proximity shapes mother-infant language exchanges in real-time.Developmental cognitive neuroscience · 2023Article
- Evidence for cultural differences in affect during mother-infant interactions.Scientific reports · 2023Article
- Measuring naturalistic proximity as a window into caregiver-child interaction patterns.Behavior research methods · 2022Article
- Neurobiology of Parental Regulation of the Infant and Its Disruption by Trauma Within Attachment.Frontiers in behavioral neuroscience · 2022Review
- Predicting their past: Machine language learning can discriminate the brains of chimpanzees with different early-life social rearing experiences.Developmental science · 2021Article
- Neurobiological changes during the peripartum period: implications for health and behavior.Social cognitive and affective neuroscience · 2020Review
- Exploring EFs and Math Abilities in Highly Deprived Contexts.Frontiers in psychology · 2020Article
- Developing a neurobehavioral animal model of poverty: Drawing cross-species connections between environments of scarcity-adversity, parenting quality, and infant outcome.Development and psychopathology · 2019Article
- Effects of early adversity on the brain: Larger-volume anterior cingulate cortex in AIDS orphans.PloS one · 2019Article
- The Relationship between Sleep and Cognitive Performance in Autism Spectrum Disorder (ASD): A Pilot Study.Children (Basel, Switzerland) · 2018Article
- Rapid Infant Prefrontal Cortex Development and Sensitivity to Early Environmental Experience.Developmental review : DR · 2018Article
- The Impact of Caregiving on the Association Between Infant Emotional Behavior and Resting State Neural Network Functional Topology.Frontiers in psychology · 2018Article
- The Neurobiological Impact of Postpartum Maternal Depression: Prevention and Intervention Approaches.Child and adolescent psychiatric clinics of North America · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Building upon the transactional model of brain development, we explore the impact of early maternal deprivation on neural development and plasticity in three neural systems: hyperactivity/impulsivity, executive function, and hypothalamic-pituitary-adrenal axis functioning across rodent, nonhuman primate, and human studies. Recognizing the complexity of early maternal-infant interactions, we limit our cross-species comparisons to data from rodent models of artificial rearing, nonhuman primate studies of peer rearing, and the relations between these two experimental approaches and human studies of children exposed to the early severe psychosocial deprivation associated with institutional care. In addition to discussing the strengths and limitations of these paradigms, we present the current state of research on the neurobiological impact of early maternal deprivation and the evidence of sensitive periods, noting methodological challenges. Integrating data across preclinical animal models and human studies, we speculate about the underlying biological mechanisms; the differential impact of deprivation due to temporal factors including onset, offset, and duration of the exposure; and the possibility and consequences of reopening of sensitive periods during adolescence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.