ArticleBiomacromolecules2015
Functional Degradable Polymers by Radical Ring-Opening Copolymerization of MDO and Vinyl Bromobutanoate: Synthesis, Degradability and Post-Polymerization Modification.
Article in Biomacromolecules, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Quantum-Chemical Study for Understanding the Low Incorporation of 2‑Methylen-1,3-Dioxepane (MDO) in Radical Ring-Opening Copolymerization with Vinyl Monomers.Macromolecules · 2026Article
- Degradable Vinyl-Based Polymers by Radical Ring-Opening Polymerization: A User Guide.ACS polymers Au · 2026Article
- Radical Ring Opening Polymerization of Cyclic Ketene Acetals Derived From d-Glucal.ACS macro letters · 2023Article
- Modifying Poly(caprolactone) Degradation through C-H Functionalization.Macromolecules · 2023Article
- Degradable polyisoprene by radical ring-opening polymerization and application to polymer prodrug nanoparticles.Chemical science · 2023Article
- Article
- Progress in the Preparation of Functional and (Bio)Degradable Polymers via Living Polymerizations.International journal of molecular sciences · 2020Review
- Article
- Article
- Metabolically Active, Fully Hydrolysable Polymersomes.Angewandte Chemie (International ed. in English) · 2019Article
- Hyperbranched Polycaprolactone through RAFT Polymerization of 2-Methylene-1,3-dioxepane.Polymers · 2019Article
- Chemoselective, Postpolymerization Modification of Bioactive, Degradable Polymers.Biomacromolecules · 2019Article
- Degradable polymer prodrugs with adjustable activity from drug-initiated radical ring-opening copolymerization.Chemical science · 2018Article
- Synthesis of Degradable Poly(vinyl alcohol) by Radical Ring-Opening Copolymerization and Ice Recrystallization Inhibition Activity.ACS macro letters · 2017Article
- Biodegradable zwitterionic sulfobetaine polymer and its conjugate with paclitaxel for sustained drug delivery.Acta biomaterialia · 2017Article
- Degradable copolymers with incorporated ester groups by radical ring-opening polymerization using atom transfer radical polymerization.Polimery · 2017Article
- Heparin-Mimicking Polymers: Synthesis and Biological Applications.Biomacromolecules · 2016Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The synthesis of vinyl bromobutanoate (VBr), a new vinyl acetate monomer derivative obtained by the palladium-catalyzed vinyl exchange reaction between vinyl acetate (VAc) and 4-bromobutyric acid is reported. The homopolymerization of this new monomer using the RAFT/MADIX polymerization technique leads to the formation of novel well-defined and controlled polymers containing pendent bromine functional groups able to be modified via postpolymerization modification. Furthermore, the copolymerization of vinyl bromobutanoate with 2-methylene-1,3-dioxepane (MDO) was also performed to deliver a range of novel functional degradable copolymers, poly(MDO-co-VBr). The copolymer composition was shown to be able to be tuned to vary the amount of ester repeat units in the polymer backbone, and hence determine the degradability, while maintaining a control of the final copolymers' molar masses. The addition of functionalities via simple postpolymerization modifications such as azidation and the 1,3-dipolar cycloaddition of a PEG alkyne to an azide is also reported and proven by (1)H NMR spectroscopy, FTIR spectroscopy, and SEC analyses. These studies enable the formation of a novel class of hydrophilic functional degradable copolymers using versatile radical polymerization methods.
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