Evidence map›Paper›PMID 25997006›Full record

ArticleInternational journal of molecular sciences2015

Proteogenomic Analysis Identifies a Novel Human SHANK3 Isoform.

Fahad Benthani, Phuong N Tran, Nicola Currey, Irvin Ng, Marc Giry-Laterriere, Louise Carey, Maija R J Kohonen-Corish, Laurent Pangon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Fahad BenthaniThe Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia. f.benthani@garvan.org.au.
Phuong N TranThe Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia. p.tran@garvan.org.au.
Nicola CurreyThe Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia. n.currey@garvan.org.au.
Irvin NgThe Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia. i.ng@garvan.org.au.
Marc Giry-LaterriereThe Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia. m.giry-laterriere@garvan.org.au.
Louise CareySydney Genome Diagnostics, the Children's Hospital at Westmead, Sydney, NSW 2145, Australia. louise.carey@health.nsw.gov.au.
Maija R J Kohonen-CorishThe Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia. m.corish@garvan.org.au.
Laurent PangonThe Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia. l.pangon@garvan.org.au.
Garvan Institute of Medical Research · AUThe Kinghorn Cancer Centre · AUChildren's Hospital at Westmead · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations of the SHANK3 gene have been associated with autism spectrum disorder. Individuals harboring different SHANK3 mutations display considerable heterogeneity in their cognitive impairment, likely due to the high SHANK3 transcriptional diversity. In this study, we report a novel interaction between the Mutated in colorectal cancer (MCC) protein and a newly identified SHANK3 protein isoform in human colon cancer cells and mouse brain tissue. Hence, our proteogenomic analysis identifies a new human long isoform of the key synaptic protein SHANK3 that was not predicted by the human reference genome. Taken together, our findings describe a potential new role for MCC in neurons, a new human SHANK3 long isoform and, importantly, highlight the use of proteomic data towards the re-annotation of GC-rich genomic regions.

Indexed as

ProteomicsAmino Acid SequenceBase SequenceCell Line, TumorHumansMolecular Sequence DataNerve Tissue ProteinsProtein BindingProtein IsoformsSequence AlignmentTumor Suppressor ProteinsMCC protein, humanNerve Tissue ProteinsProtein IsoformsSHANK3 protein, humanTumor Suppressor ProteinsMCCproteogenomicSHANK3

Identifiers

PMID25997006
PMCPMC4463715
OpenAlexW1561777010

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.