ArticlePloS one2015
Inflammatory and Metabolic Alterations of Kager's Fat Pad in Chronic Achilles Tendinopathy.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Elastography in the assessment of the Achilles tendon: a systematic review of measurement properties.Journal of foot and ankle research · 2023Pooled it
- Different Achilles Tendon Pathologies Show Distinct Histological and Molecular Characteristics.International journal of molecular sciences · 2018Trial
- Traumatic fracture of Kager's fat pad: a case report.BMC musculoskeletal disorders · 2025Article
- The potential role of GLP-1 receptor agonists in the management of psoriatic disease: a scoping review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- Anatomical and clinical relevance of Kager's triangle: diagnostic approaches and therapeutic implications for related pathologies.Journal of orthopaedic surgery and research · 2025Review
- The impact of Achilles tendon thickness and Kager's fat pad thickness on clinical and functional outcomes following open surgical repair of acute Achilles tendon rupture.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2025Article
- Injectables in the Therapy of Mid-Portion Achilles Tendinopathy, a Descriptive Review.Life (Basel, Switzerland) · 2025Review
- Erroneous Differentiation of Tendon Stem/Progenitor Cells in the Pathogenesis of Tendinopathy: Current Evidence and Future Perspectives.Stem cell reviews and reports · 2025Review
- Mitochondrial destabilization in tendinopathy and potential therapeutic strategies.Journal of orthopaedic translation · 2024Review
- Anatomical evaluations of the adipose tissue surrounding the flexor hallucis longus tendon.Scientific reports · 2024Article
- Mitochondrial mechanisms in the pathogenesis of chronic inflammatory musculoskeletal disorders.Cell & bioscience · 2024Review
- Concentrations of Selected Adipocytokines in the Blood Plasma in Proximal Suspensory Desmopathy of Horses, with a Focus on Their Physical Activity-A Pilot Study.International journal of molecular sciences · 2023Article
- Tendon healing: a concise review on cellular and molecular mechanisms with a particular focus on the Achilles tendon.Bone & joint research · 2022Article
- Inflammatory mechanisms linking obesity and tendinopathy.Journal of orthopaedic translation · 2021Review
- Association of TNF-α -308G > A polymorphism with susceptibility to tendinopathy in athletes: a case-control study.BMC sports science, medicine & rehabilitation · 2021Article
- The Kager's fat pad radiological anatomy revised.Surgical and radiologic anatomy : SRA · 2021Article
- Review: Emerging concepts in the pathogenesis of tendinopathy.The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland · 2017Review
- Ultrasound diagnosis and percutaneous treatment of Achilles tendon tethering: a case series.Skeletal radiology · 2016Article
- Procollagen markers in microdialysate can predict patient outcome after Achilles tendon rupture.BMJ open sport & exercise medicine · 2016Article
- Local effects of adipose tissue in psoriasis and psoriatic arthritis.Psoriasis (Auckland, N.Z.)Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAchilles tendinopathy is a painful inflammatory condition characterized by swelling, stiffness and reduced function of the Achilles tendon. Kager's fat pad is an adipose tissue located in the area anterior to the Achilles tendon. Observations reveal a close physical interplay between Kager's fat pad and its surrounding structures during movement of the ankle, suggesting that Kager's fat pad may stabilize and protect the mechanical function of the ankle joint.
aimThe aim of this study was to characterize whether Achilles tendinopathy was accompanied by changes in expression of inflammatory markers and metabolic enzymes in Kager's fat pad.
methodsA biopsy was taken from Kager's fat pad from 31 patients with chronic Achilles tendinopathy and from 13 healthy individuals. Gene expression was measured by reverse transcription-quantitative PCR. Focus was on genes related to inflammation and lipid metabolism.
resultsExpression of the majority of analyzed inflammatory marker genes was increased in patients with Achilles tendinopathy compared to that in healthy controls. Expression patterns of the patient group were consistent with reduced lipolysis and increased fatty acid β-oxidation. In the fat pad, the pain-signaling neuropeptide substance P was found to be present in one third of the subjects in the Achilles tendinopathy group but in none of the healthy controls.
conclusionGene expression changes in Achilles tendinopathy patient samples were consistent with Kager's fat pad being more inflamed than in the healthy control group. Additionally, the results indicate an altered lipid metabolism in Kager's fat pad of Achilles tendinopathy patients.
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