ArticlePloS one2015
Thymoquinone Inhibits Escherichia coli ATP Synthase and Cell Growth.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Thymoquinone combined with conventional antibiotics against pandrug-resistantFrontiers in pharmacology · 2026Article
- Spectroscopic Characterization and Biological Effects of 1-Oxo-bisabolone-richPlants (Basel, Switzerland) · 2024Article
- Antibacterial phenolic compounds from the flowering plants of Asia and the Pacific: coming to the light.Pharmaceutical biology · 2024Review
- In Silico and In Vitro Studies to Explore the Effect of Thymoquinone on Isocitrate Lyase, Biofilm Formation, and the Expression of Some Virulence Genes inCurrent issues in molecular biology · 2024Article
- Antibacterial and Antifungal Terpenes from the Medicinal Angiosperms of Asia and the Pacific: Haystacks and Gold Needles.Molecules (Basel, Switzerland) · 2023Review
- GSH Protects theMolecules (Basel, Switzerland) · 2022Article
- Article
- Preliminary functional analysis of the subgingival microbiota of cats with periodontitis and feline chronic gingivostomatitis.Scientific reports · 2021Article
- The Interactions between Polyphenols and Microorganisms, Especially Gut Microbiota.Antioxidants (Basel, Switzerland) · 2021Review
- A bioanalytical UHPLC based method used for the quantification of Thymoquinone-loaded-PLGA-nanoparticles in the treatment of epilepsy.BMC chemistry · 2020Article
- Corona virus versus existence of human on the earth: A computational and biophysical approach.International journal of biological macromolecules · 2020Review
- In Vitro Effect of the Common Culinary Herb Winter Savory (Foods (Basel, Switzerland) · 2020Article
- Functional importance of αAsp-350 in the catalytic sites of Escherichia coli ATP synthase.Archives of biochemistry and biophysics · 2019Article
- Neuropharmacological Potential and Delivery Prospects of Thymoquinone for Neurological Disorders.Oxidative medicine and cellular longevity · 2018Review
- A Therapeutic Connection between Dietary Phytochemicals and ATP Synthase.Current medicinal chemistry · 2017Review
- Understanding the link between antimicrobial properties of dietary olive phenolics and bacterial ATP synthase.International journal of biological macromolecules · 2017Article
- Mitochondria-targeted antioxidants as highly effective antibiotics.Scientific reports · 2017Article
- Safranal and its analogs inhibit Escherichia coli ATP synthase and cell growth.International journal of biological macromolecules · 2017Article
- Venom peptides cathelicidin and lycotoxin cause strong inhibition of Escherichia coli ATP synthase.International journal of biological macromolecules · 2016Article
- Functional importance of αIle-346 and αIle-348 in the catalytic sites of Escherichia coli ATP synthase.Archives of biochemistry and biophysics · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We examined the thymoquinone induced inhibition of purified F1 or membrane bound F1FO E. coli ATP synthase. Both purified F1 and membrane bound F1FO were completely inhibited by thymoquinone with no residual ATPase activity. The process of inhibition was fully reversible and identical in both membrane bound F1Fo and purified F1 preparations. Moreover, thymoquinone induced inhibition of ATP synthase expressing wild-type E. coli cell growth and non-inhibition of ATPase gene deleted null control cells demonstrates that ATP synthase is a molecular target for thymoquinone. This also links the beneficial dietary based antimicrobial and anticancer effects of thymoquinone to its inhibitory action on ATP synthase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.