ArticlePloS one2015
Evidence for the Presence of Glucosensor Mechanisms Not Dependent on Glucokinase in Hypothalamus and Hindbrain of Rainbow Trout (Oncorhynchus mykiss).
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Ectopic taste receptors in animal physiology: evolutionary conservation and functional diversification.Frontiers in cell and developmental biology · 2025Review
- Effects of different acute stressors on the regulation of appetite genes in the carp (Royal Society open science · 2023Article
- Exploring the potential for an evolutionarily conserved role of the taste 1 receptor gene family in gut sensing mechanisms of fish.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Viral Infection Drives the Regulation of Feeding Behavior Related Genes inInternational journal of molecular sciences · 2021Article
- Integration of Nutrient Sensing in Fish Hypothalamus.Frontiers in neuroscience · 2021Review
- Nutritional regulation of glucose metabolism-related genes in the emerging teleost model Mexican tetra surface fish: a first exploration.Royal Society open science · 2020Article
- The Melanocortin System in Atlantic Salmon (Frontiers in neuroanatomy · 2020Article
- HypothalamicFrontiers in physiology · 2020Article
- Sensing Glucose in the Central Melanocortin Circuits of Rainbow Trout: A Morphological Study.Frontiers in endocrinology · 2019Article
- Transcript levels of members of the SLC2 and SLC5 families of glucose transport proteins in eel swimbladder tissue: the influence of silvering and the influence of a nematode infection.Fish physiology and biochemistry · 2018Article
- Stress Effects on the Mechanisms Regulating Appetite in Teleost Fish.Frontiers in endocrinology · 2018Review
- Nesfatin-1 Regulates Feeding, Glucosensing and Lipid Metabolism in Rainbow Trout.Frontiers in endocrinology · 2018Article
- Sweet taste receptor in the hypothalamus: a potential new player in glucose sensing in the hypothalamus.The journal of physiological sciences : JPS · 2017Review
- Evolutionary history of glucose-6-phosphatase encoding genes in vertebrate lineages: towards a better understanding of the functions of multiple duplicates.BMC genomics · 2017Article
- Hypothalamic Integration of Metabolic, Endocrine, and Circadian Signals in Fish: Involvement in the Control of Food Intake.Frontiers in neuroscience · 2017Review
- Molecular pathways associated with the nutritional programming of plant-based diet acceptance in rainbow trout following an early feeding exposure.BMC genomics · 2016Article
- Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis.Frontiers in neuroscience · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We hypothesize that glucosensor mechanisms other than that mediated by glucokinase (GK) operate in hypothalamus and hindbrain of the carnivorous fish species rainbow trout and stress affected them. Therefore, we evaluated in these areas changes in parameters which could be related to putative glucosensor mechanisms based on liver X receptor (LXR), mitochondrial activity, sweet taste receptor, and sodium/glucose co-transporter 1 (SGLT-1) 6 h after intraperitoneal injection of 5 mL x Kg(-1) of saline solution alone (normoglycaemic treatment) or containing insulin (hypoglycaemic treatment, 4 mg bovine insulin x Kg(-1) body mass), or D-glucose (hyperglycaemic treatment, 500 mg x Kg(-1) body mass). Half of tanks were kept at a 10 Kg fish mass x m(-3) and denoted as fish under normal stocking density (NSD) whereas the remaining tanks were kept at a stressful high stocking density (70 kg fish mass x m(-3)) denoted as HSD. The results obtained in non-stressed rainbow trout provide evidence, for the first time in fish, that manipulation of glucose levels induce changes in parameters which could be related to putative glucosensor systems based on LXR, mitochondrial activity and sweet taste receptor in hypothalamus, and a system based on SGLT-1 in hindbrain. Stress altered the response of parameters related to these systems to changes in glycaemia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.