Evidence map›Paper›PMID 25996137›Full record

ArticleNeuron2015

Cux2-positive radial glial cells generate diverse subtypes of neocortical projection neurons and macroglia.

Matthew J Eckler, Ton D Nguyen, William L McKenna, Ben L Fastow, Chao Guo, John L R Rubenstein, Bin Chen

Abstract read
In one paragraph

Article in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Molecular and cellular evolution of corticogenesis in amniotes.Cellular and molecular life sciences : CMLS · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matthew J EcklerDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA.
Ton D NguyenDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA; Department of Biological Sciences, San Jose State University, San Jose, CA 95192, USA.
William L McKennaDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA.
Ben L FastowDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA.
Chao GuoDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA.
John L R RubensteinDepartment of Psychiatry and Nina Ireland Laboratory of Developmental Neurobiology, University of California, San Francisco, CA 95158, USA.
Bin ChenDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA. Electronic address: bchen@ucsc.edu.

Funding

STRUCTURE, EXPRESSION &FUNCTION OF THE DLX GENE FAMILYR01MH049428 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RUBENSTEIN, JOHN L. R. · 1992 to 2022
$5.8M
Lineage Progression of Cortical Neural Stem CellsR01NS089777 · NINDS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI CHEN, BIN · 2015 to 2025
$4.7M
GENETIC STUDIES OF CORTEX STRUCTURE AND DEVELOPMENTR01NS034661 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RUBENSTEIN, JOHN L. R. · 1996 to 2015
$4.6M
Transcriptional regulation of neuronal identity and connectivityR01MH094589 · NIMH · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI CHEN, BIN · 2011 to 2021
$3.7M
NIMH NIH HHS R01 MH049428NIMH NIH HHS R01MH049428NIMH NIH HHS R01 MH094589NIMH NIH HHS R01MH094589NINDS NIH HHS R01 NS034661NINDS NIH HHS R01 NS089777NINDS NIH HHS R01NS34661
6 · The paper itself

Abstract

We recently published genetic lineage-tracing experiments using the Fezf2 and Cux2 loci. These experiments demonstrated that at both the clonal and population levels Fezf2(+) RGCs are multipotent and that at the population level Cux2(+) RGCs are multipotent. Here, we extend our work on the lineages of Fezf2(+) and Cux2(+) RGCs. Clonal analysis of E10.5 neocortical progenitors suggests that most, if not all, Cux2(+) and Fezf2(+) RGCs generate diverse projection neuron subtypes located throughout layers 2-6. These results support our previous conclusion that both Fezf2(+) and Cux2(+) RGCs are multipotent neocortical progenitors. This Matters Arising Response paper addresses the Gil-Sanz et al. (2015) Matters Arising paper, published concurrently in Neuron.

Indexed as

Cell LineageGene Expression Regulation, DevelopmentalHomeodomain ProteinsMultipotent Stem CellsNeocortexNerve Tissue ProteinsNeurogenesisNeuronsOligodendrogliaCux2 protein, mouseHomeodomain ProteinsNerve Tissue Proteins

Identifiers

PMID25996137
PMCPMC4441766

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.