Evidence map›Paper›PMID 25996132›Full record

ReviewNeuron2015

The challenge of understanding the brain: where we stand in 2015.

John Lisman

Abstract readReview
In one paragraph

Review in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Neural bases of freedom and responsibility.Frontiers in neural circuits · 2023
    Review
  6. Article
  7. Genome Integrity and Neurological Disease.International journal of molecular sciences · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. The State of the NIH BRAIN Initiative.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. The language-ready head: Evolutionary considerations.Psychonomic bulletin & review · 2017
    Review
  17. Article
  18. Article
  19. A Spatial-Context Effect in Recognition Memory.Frontiers in behavioral neuroscience · 2017
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

John LismanBiology Department and Volen Center for Complex Systems, Brandeis University, 415 South Street, Waltham, MA 02454-9110, USA. Electronic address: lisman@brandeis.edu.

Funding

Towards a Complete Description of the Circuitry Underlying Memory replay.U01NS090583 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI SOLTESZ, IVAN · 2014 to 2016
$2.1M
Role of CaMKII in memory storageR01NS103168 · NINDS · BRANDEIS UNIVERSITY · PI GRIFFITH, LESLIE C · 2017 to 2021
$1.8M
CRCNS: Network Mechanisms Underlying Episodic MemoryR01MH102841 · NIMH · BRANDEIS UNIVERSITY · PI LISMAN, JOHN E · 2013 to 2015
$817k
Role of CaMKII in memory storageR56NS096710 · NINDS · BRANDEIS UNIVERSITY · PI GRIFFITH, LESLIE C · 2016 to 2016
$484k
NIMH NIH HHS R01 MH102841NIMH NIH HHS R01MH102841NINDS NIH HHS NS090583NINDS NIH HHS R01 NS103168NINDS NIH HHS R56 NS096710NINDS NIH HHS U01 NS090583
6 · The paper itself

Abstract

Starting with the work of Cajal more than 100 years ago, neuroscience has sought to understand how the cells of the brain give rise to cognitive functions. How far has neuroscience progressed in this endeavor? This Perspective assesses progress in elucidating five basic brain processes: visual recognition, long-term memory, short-term memory, action selection, and motor control. Each of these processes entails several levels of analysis: the behavioral properties, the underlying computational algorithm, and the cellular/network mechanisms that implement that algorithm. At this juncture, while many questions remain unanswered, achievements in several areas of research have made it possible to relate specific properties of brain networks to cognitive functions. What has been learned reveals, at least in rough outline, how cognitive processes can be an emergent property of neurons and their connections.

Indexed as

AnimalsBrainCognitionHumansMemoryMotor ActivityNeuronsNeurosciences

Identifiers

PMID25996132
PMCPMC4441769

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.