ArticleArchives of medical science : AMS2015
Serum leptin levels in gastric cancer patients and the relationship with insulin resistance.
Article in Archives of medical science : AMS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Association between Tooth Loss and Gastric Cancer: A Meta-Analysis of Observational Studies.PloS one · 2016Pooled it
- Review
- Circulating hormones and risk of gastric cancer by subsite in three cohort studies.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2023Article
- Association of Serum Leptin With Body Mass Index in Gallbladder Cancer Patients: A Pilot Study.Cureus · 2023Article
- Integrated analysis identifies AQP9 correlates with immune infiltration and acts as a prognosticator in multiple cancers.Scientific reports · 2020Article
- A Variant ofPharmacogenomics and personalized medicine · 2020Article
- Association between circulating leptin concentration andArchives of medical science : AMS · 2019Review
- Leptin is associated with disease activity but not with anthropometric indices in rheumatoid arthritis patients.Archives of medical science : AMS · 2018Article
- Immunohistochemical features and staging of early gastric cancer.Archives of medical science : AMS · 2017Article
- Functions of the AP-2α gene in activating apoptosis and inhibiting proliferation of gastric cancer cells bothArchives of medical science : AMS · 2017Article
- Lipases and lipid droplet-associated protein expression in subcutaneous white adipose tissue of cachectic patients with cancer.Lipids in health and disease · 2017Article
- Obstructive sleep apnea and hormones - a novel insight.Archives of medical science : AMS · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSerum leptin levels have been examined in various cancers, with conflicting results. However, there is limited information regarding serum leptin levels and insulin resistance in gastric cancer patients. Therefore, we aimed to investigate serum leptin levels, performance status, insulin levels and insulin resistance in patients with gastric cancer. In addition, we examined the relationship between these measurements and leptin levels. MATERIAL AND
methodsThirty-nine patients with gastric cancer and 30 control subjects were enrolled in the study. Serum leptin, total protein, albumin, growth hormone, insulin and glucose levels were measured. The homeostasis model assessment (HOMA) was used to assess insulin resistance.
resultsSerum levels of insulin, glucose and growth hormone and insulin resistance were significantly lower in gastric cancer patients than controls (p < 0.05 for all). In the Pearson correlation analysis, insulin resistance was found to be significantly correlated with serum leptin levels in gastric cancer patients (r = 0.320, p = 0.047). We observed a significant negative correlation between performance status and insulin resistance in patients with cachexia (r = -0.512, p = 0.030), while no association was found in non-cachectic patients.
conclusionsWe concluded that serum leptin levels are significantly lower in gastric cancer patients. In addition, gastric cancer patients have decreases in insulin levels, insulin resistance and growth hormone levels. This study found a positive association between serum leptin levels and insulin resistance. Moreover, there is a negative association between serum leptin levels and growth hormone levels. Thus, low insulin and growth hormone levels may suppress the production of leptin in gastric cancer patients.
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