ArticleInternational journal of nanomedicine2015
Formation of curcumin nanoparticles via solution-enhanced dispersion by supercritical CO2.
Article in International journal of nanomedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Article
- Size-dependent cryoprotective effects of curcumin nanoparticles on DNA integrity and motility in cryopreserved Angora buck sperm.Frontiers in veterinary science · 2026Article
- Application Study on the Preparation of Curcumin/PVP Coprecipitated Particles Using Coaxial Nozzle in Supercritical Antisolvent.ACS omega · 2025Article
- Characterization and safety evaluation of highly swellable polymeric nanomatrices for enhanced solubility of acyclovir.Scientific reports · 2025Article
- Preparation of curcumin submicron particles by supercritical antisolvent method with external adjustable annular gap nozzle.Scientific reports · 2025Article
- Curcumin Solubility and Bioactivity Enhancement Through Amorphization with Tryptophan via Supercritical Fluid Technology.International journal of molecular sciences · 2025Article
- Fabrication Water Solubility of Curcumin-Mogroside Self-Assembly Nanoparticles: Characterization, Antioxidant, and HepG2 Cell Cytotoxicity Activity Evaluation.International journal of food science · 2025Article
- Review of Spider Silk Applications in Biomedical and Tissue Engineering.Biomimetics (Basel, Switzerland) · 2024Review
- Physico-chemical properties of curcumin nanoparticles and its efficacy against Ehrlich ascites carcinoma.Scientific reports · 2023Article
- Applications of Curcumin and Its Nanoforms in the Treatment of Cancer.Pharmaceutics · 2023Review
- Processing and Physicochemical Properties of Magnetite Nanoparticles Coated withMaterials (Basel, Switzerland) · 2023Article
- Accelerated Simple Preparation of Curcumin-Loaded Silk Fibroin/Hyaluronic Acid Hydrogels for Biomedical Applications.Polymers · 2023Article
- New Perspective on Natural Plant Protein-Based Nanocarriers for Bioactive Ingredients Delivery.Foods (Basel, Switzerland) · 2022Review
- Dietary Plant Polyphenols as the Potential Drugs in Neurodegenerative Diseases: Current Evidence, Advances, and Opportunities.Oxidative medicine and cellular longevity · 2022Review
- Review
- Curcumin micelles entrapped in eudragit S-100 matrix: a synergistic strategy for enhanced oral delivery.Future science OA · 2021Article
- Induction of mitochondria mediated apoptosis in human ovarian cancer cells by folic acid coated tin oxide nanoparticles.PloS one · 2021Article
- Novel Technologies Based on Supercritical Fluids for the Encapsulation of Food Grade Bioactive Compounds.Foods (Basel, Switzerland) · 2020Review
- Solid and liquid state characterization of tetrahydrocurcumin using XRPD, FT-IR, DSC, TGA, LC-MS, GC-MS, and NMR and its biological activities.Journal of pharmaceutical analysis · 2020Article
- Nanocurcumin: preparation, characterization and cytotoxic effects towards human laryngeal cancer cells.RSC advances · 2020Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to enhance the bioavailability of poorly water-soluble curcumin, solution-enhanced dispersion by supercritical carbon dioxide (CO2) (SEDS) was employed to prepare curcumin nanoparticles for the first time. A 2(4) full factorial experiment was designed to determine optimal processing parameters and their influence on the size of the curcumin nanoparticles. Particle size was demonstrated to increase with increased temperature or flow rate of the solution, or with decreased precipitation pressure, under processing conditions with different parameters considered. The single effect of the concentration of the solution on particle size was not significant. Curcumin nanoparticles with a spherical shape and the smallest mean particle size of 325 nm were obtained when the following optimal processing conditions were adopted: P = 20 MPa, T = 35°C, flow rate of solution = 0.5 mL·min(-1), concentration of solution = 0.5%. Fourier transform infrared (FTIR) spectroscopy measurement revealed that the chemical composition of curcumin basically remained unchanged. Nevertheless, X-ray powder diffraction (XRPD) and thermal analysis indicated that the crystalline state of the original curcumin decreased after the SEDS process. The solubility and dissolution rate of the curcumin nanoparticles were found to be higher than that of the original curcumin powder (approximately 1.4 μg/mL vs 0.2 μg/mL in 180 minutes). This study revealed that supercritical CO2 technologies had a great potential in fabricating nanoparticles and improving the bioavailability of poorly water-soluble drugs.
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