ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Relating cerebellar purkinje cell activity to the timing and amplitude of conditioned eyelid responses.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 91 citations in OpenAlex.
- Complementary roles of cell-type-specific plasticity in shaping neocortical dynamics for learning action timing.Nature communications · 2026Article
- Cerebellar Time and Relative Time: A Comparator-Based Dynamical Timing Model and its Relevance to Psychopathology and Therapies.Cerebellum (London, England) · 2026Review
- Cerebellar structure and function abnormalities in 16p11.2 microduplication mice.Brain communications · 2026Article
- Deletion of the Voltage-Gated Calcium Channel Gene, CaCerebellum (London, England) · 2025Article
- Stimulus Contingency and Task Context Encoding within the Anterior Cingulate-Amygdala-Cerebellum Associative Learning Network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cerebellar circuit computations for predictive motor control.Nature reviews. Neuroscience · 2025Review
- A cerebello-thalamo-cortical pathway transmits reward-based post-error signals for motor timing correction during learning in male mice.Nature communications · 2025Article
- Early insights into eyeblink conditioning using optically pumped magnetometer-based MEG.Frontiers in human neuroscience · 2025Article
- The Effect of Nucleo-Olivary Stimulation on Climbing Fiber EPSPs in Purkinje Cells.Cerebellum (London, England) · 2024Article
- Mesoscale simulations predict the role of synergistic cerebellar plasticity during classical eyeblink conditioning.PLoS computational biology · 2024Article
- Emergence of syntax and word prediction in an artificial neural circuit of the cerebellum.Nature communications · 2024Article
- The ability to maintain rhythm is predictive of ADHD diagnosis and profile.BMC psychiatry · 2023Article
- Dynamic Changes in Local Activity and Network Interactions among the Anterior Cingulate, Amygdala, and Cerebellum during Associative Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- A computational passage-of-time model of the cerebellar Purkinje cell in eyeblink conditioning.Frontiers in computational neuroscience · 2023Article
- Synaptic basis of a sub-second representation of time in a neural circuit model.Nature communications · 2022Article
- Article
- Postsynaptic plasticity of Purkinje cells in mice is determined by molecular identity.Communications biology · 2022Article
- Adaptive Prediction for Social Contexts: The Cerebellar Contribution to Typical and Atypical Social Behaviors.Annual review of neuroscience · 2021Article
- The Rules of Cerebellar Learning: Around the Ito Hypothesis.Neuroscience · 2021Review
- Bidirectional learning in upbound and downbound microzones of the cerebellum.Nature reviews. Neuroscience · 2021Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
How Purkinje cell (PC) activity may be altered by learning is central to theories of the cerebellum. Pavlovian eyelid conditioning, because of how directly it engages the cerebellum, has helped reveal many aspects of cerebellar learning and the underlying mechanisms. Theories of cerebellar learning assert that climbing fiber inputs control plasticity at synapses onto PCs, and thus PCs control the expression of learned responses. We tested this assertion by recording 184 eyelid PCs and 240 non-eyelid PCs during the expression of conditioned eyelid responses (CRs) in well trained rabbits. By contrasting the responses of eyelid and non-eyelid PCs and by contrasting the responses of eyelid PCs under conditions that produce differently timed CRs, we test the hypothesis that learning-related changes in eyelid PCs contribute to the learning and adaptive timing of the CRs. We used a variety of analyses to test the quantitative relationships between eyelid PC responses and the kinematic properties of the eyelid CRs. We find that the timing of eyelid PC responses varies systematically with the timing of the behavioral CRs and that there are differences in the magnitude of eyelid PC responses between larger-CR, smaller-CR, and non-CR trials. However, eyelid PC activity does not encode any single kinematic property of the behavioral CRs at a fixed time lag, nor does it linearly encode CR amplitude. Even so, the results are consistent with the hypothesis that learning-dependent changes in PC activity contribute to the adaptively timed expression of conditioned eyelid responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.