ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
PKMζ, but not PKCλ, is rapidly synthesized and degraded at the neuronal synapse.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Protease-Containing Nanobodies for Detecting and Manipulating Intracellular Antigens Using Antiviral Drugs.ACS chemical biology · 2025Article
- Article
- KIBRA anchoring the action of PKMζ maintains the persistence of memory.Science advances · 2024Article
- KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.The Journal of clinical investigation · 2024Article
- Perineuronal nets and the neuronal extracellular matrix can be imaged by genetically encoded labeling of HAPLN1bioRxiv : the preprint server for biology · 2023Article
- The Roles of Par3, Par6, and aPKC Polarity Proteins in Normal Neurodevelopment and in Neurodegenerative and Neuropsychiatric Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Review
- Persistent increases of PKMζ in memory-activated neurons trace LTP maintenance during spatial long-term memory storage.The European journal of neuroscience · 2021Article
- Neuroprotective Effects of Adenosine A1 Receptor Signaling on Cognitive Impairment Induced by Chronic Intermittent Hypoxia in Mice.Frontiers in cellular neuroscience · 2020Article
- aPKC in neuronal differentiation, maturation and function.Neuronal signaling · 2019Review
- What does LTP tell us about the roles of CaMKII and PKMζ in memory?Molecular brain · 2018Review
- Chemogenetic control of gene expression and cell signaling with antiviral drugs.Nature methods · 2018Article
- Coupled feedback loops maintain synaptic long-term potentiation: A computational model of PKMzeta synthesis and AMPA receptor trafficking.PLoS computational biology · 2018Article
- Increased PKMζ activity impedes lateral movement of GluA2-containing AMPA receptors.Molecular brain · 2017Article
- Activity-dependent expression of Channelrhodopsin at neuronal synapses.Nature communications · 2017Article
- The genetics of PKMζ and memory maintenance.Science signaling · 2017Review
- eIF4B phosphorylation at Ser504 links synaptic activity with protein translation in physiology and pathology.Scientific reports · 2017Article
- Recent insights on principles of synaptic protein degradation.F1000Research · 2017Review
- Multicolor Electron Microscopy for Simultaneous Visualization of Multiple Molecular Species.Cell chemical biology · 2016Article
- Mechanisms of polarity protein expression control.Current opinion in cell biology · 2016Review
- The Role of Proteases in Hippocampal Synaptic Plasticity: Putting Together Small Pieces of a Complex Puzzle.Neurochemical research · 2016Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Synthesizing, localizing, and stabilizing new protein copies at synapses are crucial factors in maintaining the synaptic changes required for storing long-term memories. PKMζ recently emerged as a molecule putatively responsible for maintaining encoded memories over time because its presence correlates with late LTP and because its inhibition disrupts LTP in vitro and long-term memory storage in vivo. Here we investigated PKMζ stability in rat neurons to better understand its role during information encoding and storage. We used TimeSTAMP reporters to track the synthesis and degradation of PKMζ as well as a related atypical PKC, PKCλ. These reporters revealed that both PKMζ and PKCλ were upregulated after chemical LTP induction; however, these new PKMζ copies exhibited more rapid turnover than basally produced PKMζ, particularly in dendritic spines. In contrast to PKMζ, new PKCλ copies exhibited elevated stability. Stable information storage over long periods of time is more challenging the shorter the metabolic lifetime of the candidate molecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.