Evidence map›Paper›PMID 25995288›Full record

Observational studyAmerican journal of epidemiology2015

Dynamic Variation in Sexual Contact Rates in a Cohort of HIV-Negative Gay Men.

E O Romero-Severson, E Volz, J S Koopman, T Leitner, E L Ionides

Abstract readObservational Study
In one paragraph

Observational study in American journal of epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Panel Data Analysis via Mechanistic Models.Journal of the American Statistical Association · 2019
    Article
  5. Article
  6. Article
  7. A second-order iterated smoothing algorithm.Statistics and computing · 2017
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

E O Romero-Severson
E Volz
J S Koopman
T Leitner
E L Ionides

Funding

Reconstructing HIV Epidemics from HIV PhylogeneticsR01AI087520 · NIAID · TRIAD NATIONAL SECURITY, LLC · PI Thomas K. Leitner · 2010 to 2026
$11.2M
HIV Risk Dynamics, Genetic Patterns, and ControlR01AI078752 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOOPMAN, JAMES STEPHEN · 2008 to 2012
$2.7M
Medical Research Council MR/K010174/1NIAID NIH HHS R01 AI078752NIAID NIH HHS R01 AI087520NIAID NIH HHS R01AI087520NIAID NIH HHS R01AI78752
6 · The paper itself

Abstract

Human immunodeficiency virus (HIV) transmission models that include variability in sexual behavior over time have shown increased incidence, prevalence, and acute-state transmission rates for a given population risk profile. This raises the question of whether dynamic variation in individual sexual behavior is a real phenomenon that can be observed and measured. To study this dynamic variation, we developed a model incorporating heterogeneity in both between-person and within-person sexual contact patterns. Using novel methodology that we call iterated filtering for longitudinal data, we fitted this model by maximum likelihood to longitudinal survey data from the Centers for Disease Control and Prevention's Collaborative HIV Seroincidence Study (1992-1995). We found evidence for individual heterogeneity in sexual behavior over time. We simulated an epidemic process and found that inclusion of empirically measured levels of dynamic variation in individual-level sexual behavior brought the theoretical predictions of HIV incidence into closer alignment with reality given the measured per-act probabilities of transmission. The methods developed here provide a framework for quantifying variation in sexual behaviors that helps in understanding the HIV epidemic among gay men.

Indexed as

Models, StatisticalDisease OutbreaksHIV InfectionsHIV SeropositivityHomosexuality, MaleHumansIncidenceLikelihood FunctionsLongitudinal StudiesMaleMarkov ChainsMonte Carlo MethodPrevalenceRisk AssessmentRisk-TakingSexual Behaviordisease transmissiongay menHIVHIV riskiterated filteringpartially observed Markov processsexual behavior

Identifiers

PMID25995288
PMCPMC4517699

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.