ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2016
Nicotine Metabolism in Young Adult Daily Menthol and Nonmenthol Smokers.
Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Switching from menthol to non-menthol cigarettes does not impact acute responses to intravenous nicotine.Pharmacology, biochemistry, and behavior · 2025Trial
- Acute effects of inhaled menthol on cognitive effects of intravenous nicotine among young adult cigarette smokers.Addictive behaviors · 2021Trial
- Acute effects of inhaled menthol on the rewarding effects of intravenous nicotine in smokers.Journal of psychopharmacology (Oxford, England) · 2018Trial
- Does menthol cigarette use moderate the effect of nicotine metabolism on short-term smoking cessation?Experimental and clinical psychopharmacology · 2017Trial
- Smoking Behavior and Exposure: Results of a Menthol Cigarette Cross-over Study.American journal of health behavior · 2017Trial
- Pain and Menthol Use Are Related to Greater Nicotine Dependence Among Black Adults Who Smoke Cigarettes at Wave 5 (2018-2019) of the Population Assessment of Tobacco and Health (PATH) Study.Journal of racial and ethnic health disparities · 2023Article
- Can Treatment Support Mitigate Nicotine Metabolism-Based Disparities in Smoking Abstinence? Secondary Analysis of the Helping HAND 4 Trial.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023Article
- Nicotine self-administration with menthol and audiovisual cue facilitates differential packaging of CYP2A6 and cytokines/chemokines in rat plasma extracellular vesicles.Scientific reports · 2021Article
- Impact of menthol on nicotine intake and preference in mice: Concentration, sex, and age differences.Neuropharmacology · 2020Article
- Adolescent menthol cigarette use and risk of nicotine dependence: Findings from the national Population Assessment on Tobacco and Health (PATH) study.Drug and alcohol dependence · 2020Article
- Effects of Menthol Flavor Cigarettes or Total Urinary Menthol on Biomarkers of Nicotine and Carcinogenic Exposure and Behavioral Measures.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Article
- Genetic Polymorphism ofOpen access Macedonian journal of medical sciences · 2018Article
- Basic Science and Public Policy: Informed Regulation for Nicotine and Tobacco Products.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2018Review
- Lung cancer health disparities.Carcinogenesis · 2018Review
- E-cigarettes: Impact of E-Liquid Components and Device Characteristics on Nicotine Exposure.Current neuropharmacology · 2018Review
- Studying the interactive effects of menthol and nicotine among youth: An examination using e-cigarettes.Drug and alcohol dependence · 2017Article
- Menthol disrupts nicotine's psychostimulant properties in an age and sex-dependent manner in C57BL/6J mice.Behavioural brain research · 2017Article
- Effect of Menthol-preferring Status on Response to Intravenous Nicotine.Tobacco regulatory science · 2016Article
- Precision Medicine for Tobacco Dependence: Development and Validation of the Nicotine Metabolite Ratio.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2016Review
- Why We Must Continue to Investigate Menthol's Role in the African American Smoking Paradox.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
introductionMenthol cigarette smoking may increase the risk for tobacco smoke exposure and inhibit nicotine metabolism in the liver. Nicotine metabolism is primarily mediated by the enzyme CYP2A6 and the nicotine metabolite ratio (NMR = trans 3' hydroxycotinine/cotinine) is a phenotypic proxy for CYP2A6 activity. No studies have examined differences in this biomarker among young adult daily menthol and nonmenthol smokers. This study compares biomarkers of tobacco smoke exposure among young adult daily menthol and nonmenthol smokers.
methodsSaliva cotinine and carbon monoxide were measured in a multiethnic sample of daily smokers aged 18-35 (n = 186). Nicotine, cotinine, the cotinine/cigarette per day ratio, trans 3' hydroxycotinine, the NMR, and expired carbon monoxide were compared.
resultsThe geometric means for nicotine, cotinine, and the cotinine/cigarette per day ratio did not significantly differ between menthol and nonmenthol smokers. The NMR was significantly lower among menthol compared with nonmenthol smokers after adjusting for race/ethnicity, gender, body mass index, and cigarette smoked per day (0.19 vs. 0.24, P = .03). White menthol smokers had significantly higher cotinine/cigarettes per day ratio than white nonmenthol smokers in the adjusted model. White menthol smokers had a lower NMR in the unadjusted model (0.24 vs. 0.31, P = .05) and the differences remained marginally significant in the adjusted model (0.28 vs. 0.34, P = .06). We did not observe these differences in Native Hawaiians and Filipinos.
conclusionsYoung adult daily menthol smokers have slower rates of nicotine metabolism than nonmenthol smokers. Studies are needed to determine the utility of this biomarker for smoking cessation treatment assignments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.