ArticleScientific reports2015
Chronic kidney disease is associated with a higher 90-day mortality than other chronic medical conditions in patients with sepsis.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05887960 (Impact of Neutrophil Lymphocyte and Monocyte Lymphocyte Ratio on Chronic Kidney Disease Patients Outcome), which is not on this map. Cited by 27 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Neutrophil Lymphocyte and Monocyte Lymphocyte Ratio on Chronic Kidney Disease Patients Outcome
Who cites it
27 citing papers in PubMed.
- Fluid management for sepsis-induced hypotension in patients with advanced chronic kidney disease: a secondary analysis of the CLOVERS trial.Critical care (London, England) · 2024Trial
- Early immune anergy towards recall antigens and mitogens in patients at onset of septic shock.Scientific reports · 2018Trial
- Hydrocortisone Use for Septic Shock in Patients With CKD.Kidney international reports · 2026Article
- Soluble uric acid suppresses neutrophil-mediated host defense in sepsis.Nature communications · 2026Article
- Reproducible Identification of Staphylococcus aureus Bacteremia Clinical Subphenotypes.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Observational
- Age-Comorbidity Interactions and Clinical Outcomes in Septic Shock: An Emergency Department-Based Multicenter Cohort Study.Healthcare (Basel, Switzerland) · 2026Article
- Comparative effectiveness of finerenone versus steroidal mineralocorticoid receptor antagonists on sepsis-induced cardiomyopathy in patients with diabetic kidney disease: a real-world cohort study.Frontiers in pharmacology · 2026Article
- 'Southern African journal of infectious diseases · 2026Article
- Article
- Chest CT-derived body composition parameters for outcome prediction in sepsis patients with pneumonia.Annals of medicine · 2025Article
- Article
- The impact of comorbidities on the prognosis of patients with septic arthritis.Frontiers in medicine · 2025Review
- Early dynamic changes in platelet counts and 28-day mortality in sepsis patients: a retrospective cohort study using dynamic latent class model and generalized additive mixture model analysis.Frontiers in medicine · 2025Article
- Early Mortality Stratification with Serum Albumin and the Sequential Organ Failure Assessment Score at Emergency Department Admission in Septic Shock Patients.Life (Basel, Switzerland) · 2024Article
- The Risk Factors for Mortality among Septic Trauma Patients: A Retrospective Cohort Study Using the National Trauma Data Bank.Emergency medicine international · 2022Article
- Sepsis in end-stage renal disease patients: are they at an increased risk of mortality?Annals of medicine · 2021Article
- Red Cell Distribution Width as a Prognostic Factor and Its Comparison with Lactate in Patients with Sepsis.Diagnostics (Basel, Switzerland) · 2021Article
- Exploring the pathophysiology of post-sepsis syndrome to identify therapeutic opportunities.EBioMedicine · 2020Review
- Immune Dysfunction in Uremia 2020.Toxins · 2020Review
- Observational
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
According to previous studies, the clinical course of sepsis could be affected by preexisting medical conditions, which are very common among patients with sepsis. This observational study aimed at investigating whether common chronic medical conditions affect the 90-day mortality risk in adult Caucasian patients with sepsis. A total of 482 patients with sepsis were enrolled in this study. The ninety-day mortality was the primary outcome; organ failure was the secondary outcome. Sepsis-related organ failure assessment (SOFA) scores and the requirements for organ support were evaluated to assess organ failure. A multivariate Cox regression model for the association between the 90-day mortality risk and chronic preexisting medical conditions adjusted for all relevant confounders and mortality predictors revealed the highest hazard ratio for patients with chronic kidney disease (CKD) (hazard ratio, 2.25; 95% CI, 1.46-3.46; p = 0.0002). Patients with CKD had higher SOFA scores than patients without CKD (8.9 ± 4.0 and 6.5 ± 3.4, respectively; p < 0.0001). Additionally, an analysis of organ-specific SOFA scores revealed higher scores in three organ systems (kidney, cardiovascular and coagulation). Patients with CKD have the highest 90-day mortality risk compared with patients without CKD or with other chronic medical conditions.
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