Evidence map›Paper›PMID 25995100›Full record

Trial reportEuropean journal of applied physiology2015

Temporal dynamics of the circadian heart rate following low and high volume exercise training in sedentary male subjects.

Herbert F Jelinek, C Karmakar, A M Kiviniemi, A J Hautala, M P Tulppo, T H Mäkikallio, H V Huikuri, A H Khandoker, M Palaniswami

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Herbert F JelinekAustralian School of Advanced Medicine, Macquarie University, Sydney, Australia. hjelinek@csu.edu.au.
C KarmakarDepartment of Electrical and Electronic Engineering, University of Melbourne, Melbourne, Australia.
A M KiviniemiDepartment of Exercise and Medical Physiology, Verve Research, Oulu, Finland.
A J HautalaDepartment of Exercise and Medical Physiology, Verve Research, Oulu, Finland.
M P TulppoDepartment of Exercise and Medical Physiology, Verve Research, Oulu, Finland.
T H MäkikallioInstitute of Clinical Medicine, University of Oulu, Oulu, Finland.
H V HuikuriInstitute of Clinical Medicine, University of Oulu, Oulu, Finland.
A H KhandokerDepartment of Electrical and Electronic Engineering, University of Melbourne, Melbourne, Australia.
M PalaniswamiDepartment of Electrical and Electronic Engineering, University of Melbourne, Melbourne, Australia.
University of Melbourne · AUUniversity of Oulu · FIKhalifa University of Science and Technology · AEMacquarie University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIncreased risk of arrhythmic events occurs at certain times during the circadian cycle with the highest risk being in the second and fourth quarter of the day. Exercise improves treatment outcome in individuals with cardiovascular disease. How different exercise protocols affect the circadian rhythm and the associated decrease in adverse cardiovascular risk over the circadian cycle has not been shown.

methodsFifty sedentary male participants were randomized into an 8-week high volume and moderate volume training and a control group. Heart rate was recorded using Polar Electronics and investigated with Cosinor analysis and by Poincaré plot derived features of SD1, SD2 and the complex correlation measure (CCM) at 1-h intervals over the 24-h period.

resultsModerate exercise significantly increased vagal modulation and the temporal dynamics of the heart rate in the second quarter of the circadian cycle (p = 0.004 and p = 0.007 respectively). High volume exercise had a similar effect on vagal output (p = 0.003) and temporal dynamics (p = 0.003). Cosinor analysis confirms that the circadian heart rate displays a shift in the acrophage following moderate and high volume exercise from before waking (1st quarter) to after waking (2nd quarter of day).

conclusionsOur results suggest that exercise shifts vagal influence and increases temporal dynamics of the heart rate to the 2nd quarter of the day and suggest that this may be the underlying physiological change leading to a decrease in adverse arrhythmic events during this otherwise high-risk period.

Indexed as

Circadian RhythmExerciseHeart RateAdultHeartHumansMaleMiddle AgedSedentary BehaviorVagus NerveCircadianCosinor modelingExerciseHeart rate variability

Identifiers

PMID25995100
OpenAlexW324628721

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.