ReviewCurrent psychiatry reports2015
Neuromodulation therapies for geriatric depression.
Review in Current psychiatry reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Royal Australian and New Zealand College of Psychiatrists professional practice guidelines for the administration of repetitive transcranial magnetic stimulation.The Australian and New Zealand journal of psychiatry · 2024Guideline
- Adverse events of repetitive transcranial magnetic stimulation in older adults with depression, a systematic review of the literature.International journal of geriatric psychiatry · 2021Pooled it
- Improving Sleep Quality, Daytime Sleepiness, and Cognitive Function in Patients with Dementia by Therapeutic Exercise and NESA Neuromodulation: A Multicenter Clinical Trial.International journal of environmental research and public health · 2023Trial
- Late-Onset Depression in an Aging World: A Multidimensional Perspective on Risks, Mechanisms, and Treatment.Geriatrics (Basel, Switzerland) · 2026Review
- Cortical high-threshold and low-activation characteristics in adolescent depression: a cross-age differential analysis.Frontiers in psychiatry · 2026Article
- Development and Validation of a Risk Screening Model for Depressive Symptoms in Older Inpatients: A Cross-Sectional Study.Clinical interventions in aging · 2026Article
- Recent Advances in Multimodal Non-Pharmacological Interventions for Late-Life Depression.Neuropsychiatric disease and treatment · 2025Review
- Depression as a major component of a gait disorder-Successful multimodal treatment including electroconvulsive therapy : A case report.Zeitschrift fur Gerontologie und Geriatrie · 2023Article
- Late-life depression: Epidemiology, phenotype, pathogenesis and treatment before and during the COVID-19 pandemic.Frontiers in psychiatry · 2023Review
- The sociodemographic characteristics and clinical features of the late-life depression patients: results from the Beijing Anding Hospital mental health big data platform.BMC psychiatry · 2022Observational
- Psychedelics for Alzheimer's Disease Palliative Care.Advances in psychiatry and behavioral health · 2022Article
- The cerebellum is linked to theory of mind alterations in autism. A direct clinical and MRI comparison between individuals with autism and cerebellar neurodegenerative pathologies.Autism research : official journal of the International Society for Autism Research · 2021Article
- The Efficacy and Safety of Neuromodulation Treatments in Late-Life Depression.Current treatment options in psychiatry · 2020Article
- Efficacy of Noninvasive Brain Stimulation (tDCS or TMS) Paired with Language Therapy in the Treatment of Primary Progressive Aphasia: An Exploratory Meta-Analysis.Brain sciences · 2020Article
- Electroconvulsive Therapy for Geriatric Depression in the COVID-19 Era: Reflection on the Ethics.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2020Article
- Treatment of patients with geriatric depression with repetitive transcranial magnetic stimulation.Journal of neural transmission (Vienna, Austria : 1996) · 2019Article
- Transcranial Magnetic Stimulation (TMS) in the Elderly.Current psychiatry reports · 2018Review
- Intervention Research in Late-Life Depression: Challenges and Opportunities.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2016Article
- What the Non-Psychiatrist Should Know About Transcranial Magnetic Stimulation for Major Depression.Missouri medicineArticle
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression is frequent in old age and its prognosis is poorer than in younger populations. The use of pharmacological treatments in geriatric depression is limited by specific pharmacodynamic age-related factors that can diminish tolerability and increase the risk of drug interactions. The possibility of modulating cerebral activity using brain stimulation techniques could result in treating geriatric depression more effectively while reducing systemic side effects and medication interactions. This may subsequently improve treatment adherence and overall prognosis in the older patient. Among clinically available neuromodulatory techniques, electroconvulsive therapy (ECT) remains the gold standard for the treatment of severe depression in the elderly. Studies have proven that ECT is more effective and has a faster onset of action than antidepressants in the treatment of severe, unipolar, geriatric depression and that older age is a predictor of rapid ECT response and remission. The application of novel and more tolerable forms of ECT for geriatric depression is currently being examined. Preliminary results suggest that right unilateral ultrabrief ECT (RUL-UB ECT) is a promising intervention, with similar efficacy to brief-pulse ECT and fewer adverse cognitive effects. Overall findings in repetitive transcranial magnetic stimulation (rTMS) suggest that it is a safe intervention in geriatric depression. Higher rTMS stimulation intensity and more treatments may need to be given in the elderly to achieve optimal results. There is no specific data on vagus nerve stimulation in the elderly. Transcranial direct current stimulation, magnetic seizure therapy and deep brain stimulation are currently experimental, and more data from geriatric samples is needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.