Evidence map›Paper›PMID 25995082›Full record

ArticleCancer2015

Effectiveness of fecal immunochemical testing in reducing colorectal cancer mortality from the One Million Taiwanese Screening Program.

Han-Mo Chiu, Sam Li-Sheng Chen, Amy Ming-Fang Yen, Sherry Yueh-Hsia Chiu, Jean Ching-Yuan Fann, Yi-Chia Lee, Shin-Liang Pan, Ming-Shiang Wu, Chao-Sheng Liao, Hsiu-Hsi Chen and 2 more

3 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 137 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05163236 completednot on this mapstarted 2021, after this paper: background citation

Sensitivity of Fecal Immunochemical Test (FIT) for Colorectal Cancer (CRC) Screening and Interval Cancer Risk : a Population Based Study

TypeobservationalSponsorUniversity Hospital, BrestRan2021 to 2021Enrolled1,149ConditionsColorectal Neoplasms Malignant, Colonoscopy, Early Detection of Cancer, FemaleArmsPositive fecal immunochemical test (FIT), Negative fecal immunochemical test (FIT), Fecal immunochemical test (FIT) not performed
NCT05517343 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Impact of Real-time Notification of Colonoscopic Optical Diagnosis on Patients' Anxiety and Depression After Polypectomy: a Randomized Control Trial

TypeinterventionalSponsorFu Jen Catholic UniversityRan2022 to 2025Enrolled500ConditionsColorectal Neoplasms, Colonic Polyp, Anxiety, DepressionArmsReal-time endoscopic optical diagnosis
NCT06314971 completednot on this mapstarted 2023, after this paper: background citation

Predicting Recurrence After Curative-Intent Resection of T1 Colorectal Cancer With Transcriptomics

TypeobservationalSponsorCity of Hope Medical CenterRan2023 to 2025Enrolled138ConditionsColorectal Cancer, Colorectal Neoplasms, Colorectal Adenocarcinoma, Colorectal Cancer Stage IArmsTw1CE
3 · Its place in the literature

Who cites it

137 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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77 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Han-Mo ChiuDepartment of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Sam Li-Sheng ChenSchool of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Amy Ming-Fang YenSchool of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Sherry Yueh-Hsia ChiuDepartment of Health Care Management, College of Management, Chang Gung University, Tao-Yuan, Taiwan.
Jean Ching-Yuan FannDepartment of Health Industry Management, School of Healthcare Management, Kainan University, Tao-Yuan, Taiwan.
Yi-Chia LeeDepartment of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Shin-Liang PanDepartment of Physical Medicine and Rehabilitation, College of Medicine, National Taiwan University, Taipei, Taiwan.
Ming-Shiang WuDepartment of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chao-Sheng LiaoDepartment of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Hsiu-Hsi ChenGraduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Shin-Lan KoongHealth Promotion Administration, Ministry of Health and Welfare, Taipei, Taiwan.
Shu-Ti ChiouHealth Promotion Administration, Ministry of Health and Welfare, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe effectiveness of fecal immunochemical testing (FIT) in reducing colorectal cancer (CRC) mortality has not yet been fully assessed in a large, population-based service screening program.

methodsA prospective cohort study of the follow-up of approximately 5 million Taiwanese from 2004 to 2009 was conducted to compare CRC mortality for an exposed (screened) group and an unexposed (unscreened) group in a population-based CRC screening service targeting community residents of Taiwan who were 50 to 69 years old. Given clinical capacity, this nationwide screening program was first rolled out in 2004. In all, 1,160,895 eligible subjects who were 50 to 69 years old (ie, 21.4% of the 5,417,699 subjects of the underlying population) participated in the biennial nationwide screening program by 2009.

resultsThe actual effectiveness in reducing CRC mortality attributed to the FIT screening was 62% (relative rate for the screened group vs the unscreened group, 0.38; 95% confidence interval, 0.35-0.42) with a maximum follow-up of 6 years. The 21.4% coverage of the population receiving FIT led to a significant 10% reduction in CRC mortality (relative rate, 0.90; 95% confidence interval, 0.84-0.95) after adjustments for a self-selection bias.

conclusionsThis large, prospective Taiwanese cohort undergoing population-based FIT screening for CRC had the statistical power to demonstrate a significant CRC mortality reduction, although the follow-up time was short. Although such findings are informative for health decision makers, continued follow-up of this large cohort will be required to estimate the long-term impact of FIT screening if the covered population is expanded.

Indexed as

AgedCohort StudiesColorectal NeoplasmsEarly Detection of CancerFemaleHumansImmunohistochemistryMaleMass ScreeningMiddle AgedOccult BloodProspective StudiesTaiwancolorectal cancerfecal immunochemical testingmortality reductionpopulation-based screening

Identifiers

PMID25995082
PMCPMC4676309

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.