ArticleNeurourology and urodynamics2016
Contribution of the external urethral sphincter to urinary void size in unanesthetized unrestrained rats.
Article in Neurourology and urodynamics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- UROREC: A cystometry and electromyography recording system for analyzing urinary incontinence parameters in rat models.PloS one · 2026Article
- Functions of Interoception: From Energy Regulation to Experience of the Self.Trends in neurosciences · 2021Review
- Choice of cystometric technique impacts detrusor contractile dynamics in wistar rats.Physiological reports · 2021Article
- Efficacy of Deep Brain Stimulation on the Improvement of the Bladder Functions in Traumatic Brain Injured Rats.Brain sciences · 2020Article
- Verification and Defined Dosage of Sodium Pentobarbital for a Urodynamic Study in the Possibility of Survival Experiments in Female Rat.BioMed research international · 2020Article
- Voluntary urination control by brainstem neurons that relax the urethral sphincter.Nature neuroscience · 2018Article
- Electrical Activity of the Bladder Is Attenuated by Intravesical Inhibition of P2X2/3 Receptors During Micturition in Female Rats.International neurourology journal · 2017Article
- Spinal Transection Alters External Urethral Sphincter Activity during Spontaneous Voiding in Freely Moving Rats.Journal of neurotrauma · 2017Article
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4 authors at 2 institutions in 1 country.
Funding
Abstract
aimsIn anesthetized rats, voiding is typically associated with phasic activation (bursting) of the external urethral sphincter (EUS). During spontaneous voiding in unanesthetized, unrestrained rats, EUS bursting is the most common form of EUS activity exhibited, but it is not necessary for productive voiding to occur. The aim of the present study was to determine which aspects of EUS activity contributed to void size during bursting and non-bursting voiding in conscious, freely moving rats.
methodsFemale rats were implanted with electrodes adjacent to the EUS for recording electromyographic activity (EMG). EUS EMG recordings were performed during 24-hr sessions in a metabolic cage while voided urine was continuously collected and weighed.
resultsVoid size was positively correlated with the duration of the intra-burst silent and active periods and variables reflecting the overall intensity and duration of bursting, particularly at lower frequencies within the 3-10 Hz range of EUS bursting. In addition, void size was inversely related to the frequency of bursting and to the average EMG amplitude during voiding, both in voids with and without bursting.
conclusionsEUS bursting contributes to productive voiding when bursting is present. Lower bursting frequencies elicit more productive voiding than do higher frequencies. In the absence of bursting, the association of increased void size with smaller average EUS EMG amplitude suggests that conscious rats can perform synergic voiding (i.e., bladder contraction with EUS relaxation) that is comparable to that seen in humans and other typically non-bursting species. Neurourol. Urodynam. 35:696-702, 2016. © 2015 Wiley Periodicals, Inc.
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