Evidence map›Paper›PMID 25995055›Full record

ArticleNeurology2015

Quality of life in idiopathic intracranial hypertension at diagnosis: IIH Treatment Trial results.

Kathleen B Digre, Beau B Bruce, Michael P McDermott, Kristin M Galetta, Laura J Balcer, Michael Wall, NORDIC Idiopathic Intracranial Hypertension Study Group

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 3 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 106 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Interventions for idiopathic intracranial hypertension.The Cochrane database of systematic reviews · 2015
    Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Article
  10. Article
  11. Review
  12. Prediction of Poor Visual Outcomes at Idiopathic Intracranial Hypertension Diagnosis Using a Supervised Machine Learning Algorithm.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2025
    Article
  13. Article
  14. Observational
  15. Article
  16. Longitudinal Visual Outcomes and Risk of Papilledema Recurrence in Fulminant Idiopathic Intracranial Hypertension.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2025
    Article
  17. Article
  18. Review
  19. Article
  20. Venous sinus stenosis intracranial hypertension, rethinking idiopathic intracranial hypertension in the setting of venous sinus stenosis: A call for new nomenclature and diagnostic precision.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Kathleen B DigreFrom the Moran Eye Center (K.B.D.), University of Utah, Salt Lake City; Departments of Ophthalmology, Neurology, and Epidemiology (B.B.B.), Emory University, Atlanta, GA; Departments of Biostatistics and Computational Biology and Neurology (M.P.M.), and Center for Human Experimental Therapeutics, University of Rochester Medical Center, NY; Department of Neurology (K.M.G.), University of Pennsylvania School of Medicine, Philadelphia; Departments of Neurology and Ophthalmology (L.J.B.), New York University; and Department of Ophthalmology and Visual Sciences (M.W.), University of Iowa Carver College of Medicine, Iowa City. kathleen.digre@hsc.utah.edu.
Beau B BruceFrom the Moran Eye Center (K.B.D.), University of Utah, Salt Lake City; Departments of Ophthalmology, Neurology, and Epidemiology (B.B.B.), Emory University, Atlanta, GA; Departments of Biostatistics and Computational Biology and Neurology (M.P.M.), and Center for Human Experimental Therapeutics, University of Rochester Medical Center, NY; Department of Neurology (K.M.G.), University of Pennsylvania School of Medicine, Philadelphia; Departments of Neurology and Ophthalmology (L.J.B.), New York University; and Department of Ophthalmology and Visual Sciences (M.W.), University of Iowa Carver College of Medicine, Iowa City.
Michael P McDermottFrom the Moran Eye Center (K.B.D.), University of Utah, Salt Lake City; Departments of Ophthalmology, Neurology, and Epidemiology (B.B.B.), Emory University, Atlanta, GA; Departments of Biostatistics and Computational Biology and Neurology (M.P.M.), and Center for Human Experimental Therapeutics, University of Rochester Medical Center, NY; Department of Neurology (K.M.G.), University of Pennsylvania School of Medicine, Philadelphia; Departments of Neurology and Ophthalmology (L.J.B.), New York University; and Department of Ophthalmology and Visual Sciences (M.W.), University of Iowa Carver College of Medicine, Iowa City.
Kristin M GalettaFrom the Moran Eye Center (K.B.D.), University of Utah, Salt Lake City; Departments of Ophthalmology, Neurology, and Epidemiology (B.B.B.), Emory University, Atlanta, GA; Departments of Biostatistics and Computational Biology and Neurology (M.P.M.), and Center for Human Experimental Therapeutics, University of Rochester Medical Center, NY; Department of Neurology (K.M.G.), University of Pennsylvania School of Medicine, Philadelphia; Departments of Neurology and Ophthalmology (L.J.B.), New York University; and Department of Ophthalmology and Visual Sciences (M.W.), University of Iowa Carver College of Medicine, Iowa City.
Laura J BalcerFrom the Moran Eye Center (K.B.D.), University of Utah, Salt Lake City; Departments of Ophthalmology, Neurology, and Epidemiology (B.B.B.), Emory University, Atlanta, GA; Departments of Biostatistics and Computational Biology and Neurology (M.P.M.), and Center for Human Experimental Therapeutics, University of Rochester Medical Center, NY; Department of Neurology (K.M.G.), University of Pennsylvania School of Medicine, Philadelphia; Departments of Neurology and Ophthalmology (L.J.B.), New York University; and Department of Ophthalmology and Visual Sciences (M.W.), University of Iowa Carver College of Medicine, Iowa City.
Michael WallFrom the Moran Eye Center (K.B.D.), University of Utah, Salt Lake City; Departments of Ophthalmology, Neurology, and Epidemiology (B.B.B.), Emory University, Atlanta, GA; Departments of Biostatistics and Computational Biology and Neurology (M.P.M.), and Center for Human Experimental Therapeutics, University of Rochester Medical Center, NY; Department of Neurology (K.M.G.), University of Pennsylvania School of Medicine, Philadelphia; Departments of Neurology and Ophthalmology (L.J.B.), New York University; and Department of Ophthalmology and Visual Sciences (M.W.), University of Iowa Carver College of Medicine, Iowa City.
NORDIC Idiopathic Intracranial Hypertension Study Group
New York University · USEmory University · USUniversity of Pennsylvania · USUniversity of Utah · USUniversity of Rochester Medical Center · US

Funding

Neuro-Ophthalmology Research Disease Investigator Consortium (NORDIC) NetworkU10EY017281 · NEI · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI KUPERSMITH, MARK J · 2009 to 2014
$10.2M
Data Coordination and Biostatistics Center for the NORDIC NetworkU10EY017387 · NEI · UNIVERSITY OF ROCHESTER · PI KIEBURTZ, KARL D. · 2009 to 2013
$7.0M
Ocular fundus photos in the emergency room: a new application for telemedicine?K23EY019341 · NEI · EMORY UNIVERSITY · PI BRUCE, BEAU BENJAMIN · 2010 to 2014
$718k
NEI NIH HHS 1U10EY017281-01A1NEI NIH HHS 1U10EY017387-01A1NEI NIH HHS 1U10EY017387-01A1S1NEI NIH HHS 3U10EY017281-01A1S1NEI NIH HHS 3U10EY017281-01A1S2NEI NIH HHS K23 EY019341NEI NIH HHS K23EY019341NEI NIH HHS U10 EY017281NEI NIH HHS U10 EY017387
6 · The paper itself

Abstract

objectiveThe study purpose was to examine vision-specific and overall health-related quality of life (QOL) at baseline in Idiopathic Intracranial Hypertension Treatment Trial patients who were newly diagnosed and had mild visual loss. We also sought to determine the associations between vision-specific QOL scores and visual symptoms, visual function, pain, headache-related disability, and obesity.

methodsWe assessed QOL using the 36-Item Short Form Health Survey, National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ-25), and 10-Item NEI-VFQ-25 Neuro-Ophthalmic Supplement. We compared these results with those of previously reported idiopathic intracranial hypertension (IIH) QOL studies. We assessed relationships between QOL and other clinical characteristics.

resultsAmong 165 participants with IIH (161 women and 4 men with a mean age ± SD of 29.2 ± 7.5 years), vision-specific QOL scores were reduced compared with published values for disease-free controls. Scores of participants were comparable to published results for patients with multiple sclerosis and a history of optic neuritis. A multiple linear regression model for the NEI-VFQ-25 composite score found that perimetric mean deviation in the best eye, visual acuity in the worst eye, visual symptoms, and pain symptoms (headache, neck pain), but not obesity, were independently associated with QOL.

conclusionsIIH affects QOL at time of diagnosis even in patients with mild visual impairment. Vision-specific QOL in patients with newly diagnosed IIH may be as decreased as that for patients with other neuro-ophthalmic disorders. IIH treatment should target visual loss and other symptoms of increased intracranial pressure associated with reduced QOL. Reduced QOL does not simply reflect obesity, an underlying IIH risk factor.

Indexed as

Quality of LifeAdultCross-Sectional StudiesFemaleHumansIntracranial HypertensionLinear ModelsMaleRandomized Controlled Trials as TopicSurveys and QuestionnairesVision, LowVision Tests

Identifiers

PMID25995055
PMCPMC4478032
OpenAlexW2125601016

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.