ArticleJournal of human genetics2015
Genome-wide signatures of male-mediated migration shaping the Indian gene pool.
Article in Journal of human genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Reconstructing the population history of the Nicobarese.European journal of human genetics : EJHG · 2024Article
- Contrasting maternal and paternal genetic histories among five ethnic groups from Khyber Pakhtunkhwa, Pakistan.Scientific reports · 2022Article
- Mitochondrial DNA diversity in the Khattak and Kheshgi of the Peshawar Valley, Pakistan.Genetica · 2020Article
- Munda languages are father tongues, but Japanese and Korean are not.Evolutionary human sciences · 2020Review
- Article
- WhoGEM: an admixture-based prediction machine accurately predicts quantitative functional traits in plants.Genome biology · 2019Article
- Bioinformatics research at BGRS-2018.BMC bioinformatics · 2019Article
- Ancient Human Migrations to and through Jammu Kashmir- India were not of Males Exclusively.Scientific reports · 2018Article
- Between Lake Baikal and the Baltic Sea: genomic history of the gateway to Europe.BMC genetics · 2017Article
- Article
- Clinical utility of the low-density Infinium QC genotyping Array in a genomics-based diagnostics laboratory.BMC medical genomics · 2017Article
- Toward high-resolution population genomics using archaeological samples.DNA research : an international journal for rapid publication of reports on genes and genomes · 2016Review
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Authors and funding
12 authors.
Funding
Abstract
Multiple questions relating to contributions of cultural and demographical factors in the process of human geographical dispersal remain largely unanswered. India, a land of early human settlement and the resulting diversity is a good place to look for some of the answers. In this study, we explored the genetic structure of India using a diverse panel of 78 males genotyped using the GenoChip. Their genome-wide single-nucleotide polymorphism (SNP) diversity was examined in the context of various covariates that influence Indian gene pool. Admixture analysis of genome-wide SNP data showed high proportion of the Southwest Asian component in all of the Indian samples. Hierarchical clustering based on admixture proportions revealed seven distinct clusters correlating to geographical and linguistic affiliations. Convex hull overlay of Y-chromosomal haplogroups on the genome-wide SNP principal component analysis brought out distinct non-overlapping polygons of F*-M89, H*-M69, L1-M27, O2a-M95 and O3a3c1-M117, suggesting a male-mediated migration and expansion of the Indian gene pool. Lack of similar correlation with mitochondrial DNA clades indicated a shared genetic ancestry of females. We suggest that ancient male-mediated migratory events and settlement in various regional niches led to the present day scenario and peopling of India.
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