Evidence map›Paper›PMID 25994812›Full record

ArticleInternational journal of radiation biology2015

Combined immunomodulator and antimicrobial therapy eliminates polymicrobial sepsis and modulates cytokine production in combined injured mice.

Thomas B Elliott, David L Bolduc, G David Ledney, Juliann G Kiang, Oluseyi O Fatanmi, Stephen Y Wise, Patricia L P Romaine, Victoria L Newman, Vijay K Singh

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of radiation biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome.American journal of physiology. Gastrointestinal and liver physiology · 2020
    Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Thomas B Elliotta Armed Forces Radiobiology Research Institute , Bethesda , MD , USA.
David L Bolduca Armed Forces Radiobiology Research Institute , Bethesda , MD , USA.
G David Ledneya Armed Forces Radiobiology Research Institute , Bethesda , MD , USA.
Juliann G Kianga Armed Forces Radiobiology Research Institute , Bethesda , MD , USA.
Oluseyi O Fatanmia Armed Forces Radiobiology Research Institute , Bethesda , MD , USA.
Stephen Y Wisea Armed Forces Radiobiology Research Institute , Bethesda , MD , USA.
Patricia L P Romainea Armed Forces Radiobiology Research Institute , Bethesda , MD , USA.
Victoria L Newmana Armed Forces Radiobiology Research Institute , Bethesda , MD , USA.
Vijay K Singha Armed Forces Radiobiology Research Institute , Bethesda , MD , USA.
Armed Forces Institute of Pathology · USUniformed Services University of the Health Sciences · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeA combination therapy for combined injury (CI) using a non-specific immunomodulator, synthetic trehalose dicorynomycolate and monophosphoryl lipid A (STDCM-MPL), was evaluated to augment oral antimicrobial agents, levofloxacin (LVX) and amoxicillin (AMX), to eliminate endogenous sepsis and modulate cytokine production. MATERIALS AND

methodsFemale B6D2F(1)/J mice received 9.75 Gy cobalt-60 gamma-radiation and wound. Bacteria were isolated and identified in three tissues. Incidence of bacteria and cytokines were compared between treatment groups.

resultsResults demonstrated that the lethal dose for 50% at 30 days (LD(50/30)) of B6D2F(1)/J mice was 9.42 Gy. Antimicrobial therapy increased survival in radiation-injured (RI) mice. Combination therapy increased survival after RI and extended survival time but did not increase survival after CI. Sepsis began five days earlier in CI mice than RI mice with Gram-negative species predominating early and Gram-positive species increasing later. LVX plus AMX eliminated sepsis in CI and RI mice. STDCM-MPL eliminated Gram-positive bacteria in CI and most RI mice but not Gram-negative. Treatments significantly modulated 12 cytokines tested, which pertain to wound healing or elimination of infection.

conclusionsCombination therapy eliminates infection and prolongs survival time but does not assure CI mouse survival, suggesting that additional treatment for proliferative-cell recovery is required.

Indexed as

AmoxicillinAnimalsAnti-Infective AgentsBacterial InfectionsChemokinesCord FactorsCytokinesDisease Models, AnimalDrug Therapy, CombinationFemaleGamma RaysGrowth SubstancesImmunologic FactorsLevofloxacinLipid AMice6,6'-dicorynomycolyl trehaloseAmoxicillinAnti-Infective AgentsChemokinesCord FactorsCytokinesGrowth SubstancesImmunologic FactorsLevofloxacinLipid Amonophosphoryl lipid AAnti-microbial therapybacterial translocationchemokinescytokinesgamma-radiationimmunomodulatorinfectionmicesepsis

Identifiers

PMID25994812
PMCPMC4673550
OpenAlexW2152453552

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.