Evidence map›Paper›PMID 25994805›Full record

ArticleInternational journal of obesity (2005)2015

Distinct regulation of hypothalamic and brown/beige adipose tissue activities in human obesity.

B Rachid, S van de Sande-Lee, S Rodovalho, F Folli, G C Beltramini, J Morari, B J Amorim, T Pedro, A F Ramalho, B Bombassaro and 8 more

Registry-linked trialAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in International journal of obesity (2005), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04385615 (Effect of Fasting Mimicking Diet on the Activation of Beige/Brown Adipose Tissue in Humans), which is not on this map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04385615 nawithdrawnnot on this mapstarted 2021, after this paper: background citation

Effect of Fasting Mimicking Diet on the Activation of Beige/Brown Adipose Tissue in Humans

TypeinterventionalSponsorUniversity of Campinas, BrazilRan2021 to 2022Enrolled0ConditionsObesityArmsFasting Mimicking Diet
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. DUODENAL-JEJUNAL BYPASS REDUCES LIPID ACCUMULATION IN THE BROWN ADIPOSE TISSUE OF HYPOTHALAMIC OBESE RATS.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2020
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Brown Adipose Tissue Energy Metabolism in Humans.Frontiers in endocrinology · 2018
    Review
  18. Observational
  19. Article
  20. Inter-organ regulation of adipose tissue browning.Cellular and molecular life sciences : CMLS · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 2 countries.

B RachidLaboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, Brazil.
S van de Sande-LeeLaboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, Brazil.
S RodovalhoLaboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, Brazil.
F FolliDepartment of Medicine, Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
G C BeltraminiNeurophysics Group, Institute of Physics Gleb Wataghin, University of Campinas, Campinas, Brazil.
J MorariLaboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, Brazil.
B J AmorimDivision of Nuclear Medicine, Department of Radiology, University of Campinas, Campinas, Brazil.
T PedroNeuroimaging Laboratory, Department of Neurology, University of Campinas, Campinas, Brazil.
A F RamalhoLaboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, Brazil.
B BombassaroLaboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, Brazil.
A J TincaniDepartment of Surgery, University of Campinas, Campinas, Brazil.
E ChaimDepartment of Surgery, University of Campinas, Campinas, Brazil.
J C ParejaDepartment of Surgery, University of Campinas, Campinas, Brazil.
B GelonezeLaboratory of Investigation in Metabolism and Diabetes, University of Campinas, Campinas, Brazil.ORCID http://orcid.org/0000-0002-0557-4578
C D RamosDivision of Nuclear Medicine, Department of Radiology, University of Campinas, Campinas, Brazil.
F CendesNeuroimaging Laboratory, Department of Neurology, University of Campinas, Campinas, Brazil.ORCID http://orcid.org/0000-0001-9336-9568
M J A SaadLaboratory of Experimental Endocrinology, Department of Internal Medicine, University of Campinas, Campinas, Brazil.
L A VellosoLaboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, Brazil.
Universidade Estadual de Campinas (UNICAMP) · BRThe University of Texas Health Science Center at San Antonio · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesThe identification of brown/beige adipose tissue in adult humans has motivated the search for methods aimed at increasing its thermogenic activity as an approach to treat obesity. In rodents, the brown adipose tissue is under the control of sympathetic signals originating in the hypothalamus. However, the putative connection between the depots of brown/beige adipocytes and the hypothalamus in humans has never been explored. The objective of this study was to evaluate the response of the hypothalamus and brown/beige adipose tissue to cold stimulus in obese subjects undergoing body mass reduction following gastric bypass. SUBJECTS/

methodsWe evaluated twelve obese, non-diabetic subjects undergoing Roux-in-Y gastric bypass and 12 lean controls. Obese subjects were evaluated before and approximately 8 months after gastric bypass. Lean subjects were evaluated only at admission. Subjects were evaluated for hypothalamic activity in response to cold by functional magnetic resonance, whereas brown/beige adipose tissue activity was evaluated using a (F 18) fluorodeoxyglucose positron emisson tomography/computed tomography scan and real-time PCR measurement of signature genes.

resultsBody mass reduction resulted in a significant increase in brown/beige adipose tissue activity in response to cold; however, no change in cold-induced hypothalamic activity was observed after body mass reduction. No correlation was found between brown/beige adipose tissue activation and hypothalamus activity in obese subjects or in lean controls.

conclusionsIn humans, the increase in brown/beige adipose tissue activity related to body mass reduction occurs independently of changes in hypothalamic activity as determined by functional magnetic resonance.

Indexed as

Gastric BypassPositron-Emission TomographyAdaptation, PhysiologicalAdipose Tissue, BrownAdultBrazilCold TemperatureFemaleFluorodeoxyglucose F18Gene Expression RegulationHumansHypothalamusMitochondrial ProteinsObesityRadiopharmaceuticalsReal-Time Polymerase Chain ReactionFluorodeoxyglucose F18Mitochondrial ProteinsRadiopharmaceuticals

Identifiers

PMID25994805
OpenAlexW2279979472

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.