Evidence map›Paper›PMID 25994612›Full record

ArticleClinical rheumatology2016

Severe vitamin D deficiency in patients with Kawasaki disease: a potential role in the risk to develop heart vascular abnormalities?

Stefano Stagi, Donato Rigante, Gemma Lepri, Marco Matucci Cerinic, Fernanda Falcini

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical rheumatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 5 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 5 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
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  6. Vitamin D and Kawasaki disease.Frontiers in pharmacology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Stefano StagiHealth Sciences Department, University of Florence, Anna Meyer Children's University Hospital, Florence, Italy.
Donato RiganteInstitute of Pediatrics, Università Cattolica Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy.
Gemma LepriDepartment of Experimental and Clinical Medicine and Department of Biomedicine, Division of Rheumatology, Transition Clinic, University of Florence, Viale Pieraccini 18, 50139, Florence, Italy.
Marco Matucci CerinicDepartment of Experimental and Clinical Medicine and Department of Biomedicine, Division of Rheumatology, Transition Clinic, University of Florence, Viale Pieraccini 18, 50139, Florence, Italy.
Fernanda FalciniDepartment of Experimental and Clinical Medicine and Department of Biomedicine, Division of Rheumatology, Transition Clinic, University of Florence, Viale Pieraccini 18, 50139, Florence, Italy. falcini@unifi.it.
University of Florence · ITAgostino Gemelli University Polyclinic · ITMeyer Children's Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Twenty-five-hydroxyvitamin D (25(OH)-vitamin D) is crucial in the regulation of immunologic processes, but-although its deficiency has been reported in patients with different rheumatological disorders-no data are available for Kawasaki disease (KD). The goals of this study were to assess the serum levels of 25(OH)-vitamin D in children with KD and evaluate the relationship with the eventual occurrence of KD-related vascular abnormalities. We evaluated serum 25(OH)-vitamin D levels in 79 children with KD (21 females, 58 males, median age 4.9 years, range 1.4-7.5 years) in comparison with healthy sex-/age-matched controls. A significantly higher percentage of KD patients (98.7 %) were shown to have reduced 25(OH)-vitamin D levels (<30 ng/mL) in comparison with controls (78.6 %, p < 0.0001). Furthermore, KD patients had severely low levels of 25(OH)-vitamin D than controls (9.17 ± 4.94 vs 23.3 ± 10.6 ng/mL, p < 0.0001), especially the subgroup who developed coronary artery abnormalities (4.92 ± 1.36 vs 9.41 ± 4.95 ng/mL, p < 0.0001). In addition, serum 25(OH)-vitamin D levels correlated not only with erythrosedimentation rate (p < 0.0001), C-reactive protein (p < 0.0001), hemoglobin level at KD diagnosis (p < 0.0001) but also with both coronary artery aneurysms (p = 0.005) and non-aneurysmatic cardiovascular lesions (p < 0.05). Low serum concentrations of 25(OH)-vitamin D might have a contributive role in the development of coronary artery complications observed in children with KD.

Indexed as

Case-Control StudiesChildChild, PreschoolCoronary Vessel AnomaliesC-Reactive ProteinFemaleHumansInfantItalyLinear ModelsMaleMucocutaneous Lymph Node SyndromeMultivariate AnalysisRisk FactorsVitamin DVitamin D DeficiencyC-Reactive ProteinVitamin D25(OH)-vitamin DCoronary artery aneurysmsKawasaki disease

Identifiers

PMID25994612
OpenAlexW218838930

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.