ArticlePsycho-oncology2016
Social support and its implications in older, early-stage breast cancer patients in CALGB 49907 (Alliance A171301).
Article in Psycho-oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Capecitabine for hormone receptor-positive versus hormone receptor-negative breast cancer.The Cochrane database of systematic reviews · 2021Pooled it
- The clinical effect evaluation of multidisciplinary collaborative team combined with palliative care model in patients with terminal cancer: a randomised controlled study.BMC palliative care · 2023Trial
- Randomized Trial of Standard Adjuvant Chemotherapy Regimens Versus Capecitabine in Older Women With Early Breast Cancer: 10-Year Update of the CALGB 49907 Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2019Trial
- Impact of social support on cognitive function in patients with breast cancer undergoing chemotherapy: The chain-mediating role of fatigue and depression.Asia-Pacific journal of oncology nursing · 2025Article
- Psychosocial Support and Cost Burden of Cancer Among Patients Attending Tertiary Oncology Clinics in Lagos State, Nigeria.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- The Prognostic Utility of a Geriatric Assessment for Patients with Pancreatic Cancer Receiving Gemcitabine-based Chemotherapy: A Prospective Observational Study.Internal medicine (Tokyo, Japan) · 2023Observational
- Psychosocial needs of older patients with metastatic breast cancer treated at community centers.Journal of geriatric oncology · 2023Article
- Social support and cervical cancer screening among sub-Saharan African immigrant (SAI) women.Cancer causes & control : CCC · 2022Article
- Social support and outcomes in older adults with lung cancer.Journal of geriatric oncology · 2022Article
- Social support for older adults with cancer: Young International Society of Geriatric Oncology review paper.Journal of geriatric oncology · 2020Review
- Arti Hurria, M.D.: A tribute to her shining legacy in the Alliance for Clinical Trials in Oncology.Journal of geriatric oncology · 2020Article
- Feasibility of radiotherapy in nonagenarian patients: a retrospective study.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2019Article
- Social support following diagnosis and treatment for colorectal cancer and associations with health-related quality of life: Results from the UK ColoREctal Wellbeing (CREW) cohort study.Psycho-oncology · 2017Article
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Authors and funding
12 authors at 9 institutions in 1 country.
Funding
Abstract
backgroundStudies point to a direct association between social support and better cancer outcomes. This study examined whether baseline social support is associated with better survival and fewer chemotherapy-related adverse events in older, early-stage breast cancer patients.
methodsThis study is a pre-planned secondary analysis of CALGB 49907/Alliance A171301, a randomized trial that compared standard adjuvant chemotherapy versus capecitabine in breast cancer patients 65 years of age or older. A subset reported on the extent of their social support with questionnaires that were completed 6 times over 2 years.
resultsThe median age of this 331-patient cohort was 72 years (range: 65, 90); 179 (55%) were married, and 210 (65%) lived with someone. One hundred forty-five patients (46%) described a social network of 0-10 people; 110 (35%) of 11-25; and 58 (19%) of 26 or more. The Medical Outcomes Study (MOS) social support survey revealed that the median scores (range) for emotional/informational, tangible, positive social interaction, and affectionate social support were 94 (3, 100), 94 (0, 100), 96 (0, 100), and 100 (8, 100), respectively. Social support scores appeared stable over 2 years and higher (more support) than in other cancer settings. No statistically significant associations were observed between social support and survival and adverse events in multivariate analyses. However, married patients had smaller tumors, and those with arthritis reported less social support.
conclusionAlthough social support did not predict survival and adverse events, the exploratory but plausible inverse associations with larger tumors and arthritis suggest that social support merits further study.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.