Evidence map›Paper›PMID 25994296›Full record

ArticleJournal of the Royal Society, Interface2015

Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema.

David M L Lilburn, Clémentine Lesbats, Joseph S Six, Eric Dubuis, Liang Yew-Booth, Dominick E Shaw, Maria G Belvisi, Mark A Birrell, Galina E Pavlovskaya, Thomas Meersmann

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Royal Society, Interface, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Molecular hydrogen and catalytic combustion in the production of hyperpolarized 83Kr and 129Xe MRI contrast agents.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

David M L LilburnSir Peter Mansfield Imaging Centre, Division for Respiratory Medicine, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK.
Clémentine LesbatsSir Peter Mansfield Imaging Centre, Division for Respiratory Medicine, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK.
Joseph S SixSir Peter Mansfield Imaging Centre, Division for Respiratory Medicine, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK.
Eric DubuisRespiratory Pharmacology, Pharmacology and Toxicology, Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
Liang Yew-BoothRespiratory Pharmacology, Pharmacology and Toxicology, Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
Dominick E ShawCity Hospital Nottingham, Nottingham Respiratory Research Unit, Nottingham NG5 1PB, UK.
Maria G BelvisiRespiratory Pharmacology, Pharmacology and Toxicology, Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
Mark A BirrellRespiratory Pharmacology, Pharmacology and Toxicology, Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
Galina E PavlovskayaSir Peter Mansfield Imaging Centre, Division for Respiratory Medicine, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK.
Thomas MeersmannSir Peter Mansfield Imaging Centre, Division for Respiratory Medicine, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK thomas.meersmann@nottingham.ac.uk.
University of Nottingham · GBImperial College London · GBNottingham City Hospital · GB

Funding

Medical Research Council G0900785
6 · The paper itself

Abstract

Hyperpolarized (83)Kr surface quadrupolar relaxation (SQUARE) generates MRI contrast that was previously shown to correlate with surface-to-volume ratios in porous model surface systems. The underlying physics of SQUARE contrast is conceptually different from any other current MRI methodology as the method uses the nuclear electric properties of the spin I = 9/2 isotope (83)Kr. To explore the usage of this non-radioactive isotope for pulmonary pathophysiology, MRI SQUARE contrast was acquired in excised rat lungs obtained from an elastase-induced model of emphysema. A significant (83)Kr T1 relaxation time increase in the SQUARE contrast was found in the elastase-treated lungs compared with the baseline data from control lungs. The SQUARE contrast suggests a reduction in pulmonary surface-to-volume ratio in the emphysema model that was validated by histology. The finding supports usage of (83)Kr SQUARE as a new biomarker for surface-to-volume ratio changes in emphysema.

Indexed as

Models, TheoreticalAnimalsContrast MediaDisease Models, AnimalKryptonMagnetic Resonance ImagingPulmonary AlveoliPulmonary EmphysemaRadiographyRatsContrast MediaKryptonanimal model emphysemahyperpolarized noble gas MRIkrypton-83nuclear electric quadrupolar relaxationpulmonary imagingsurface-sensitive contrast

Identifiers

PMID25994296
PMCPMC4587540
OpenAlexW2278620852

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.